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    Eid3 EP300 interacting inhibitor of differentiation 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691688, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eid3provided by RGD
    Official Full Name
    EP300 interacting inhibitor of differentiation 3provided by RGD
    Primary source
    RGD:1597206
    See related
    AllianceGenome:RGD:1597206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NS4EB
    Summary
    Predicted to be involved in DNA repair. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human EID3 (EP300 interacting inhibitor of differentiation 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22747645..22748967, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20860073..20861395, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26976154..26977479, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene uncharacterized LOC134479651 Neighboring gene uncharacterized LOC134479652 Neighboring gene thioredoxin reductase 1 Neighboring gene uncharacterized LOC108351425 Neighboring gene uncharacterized LOC134479653

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. Sasajima Y, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15970276
    2. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114449

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EP300-interacting inhibitor of differentiation 3
    Names
    E1A-like inhibitor of differentiation 3
    EID-1-like inhibitor of differentiation 3
    EID-3
    non-SMC element 4 homolog B
    non-structural maintenance of chromosomes element 4 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044304.1 → NP_001037769.2  EP300-interacting inhibitor of differentiation 3

      See identical proteins and their annotated locations for NP_001037769.2

      Status: VALIDATED

      Source sequence(s)
      BC097404
      UniProtKB/Swiss-Prot
      Q4V8G2
      UniProtKB/TrEMBL
      A6IFH7
      Conserved Domains (3) summary
      pfam08743
      Location:295 → 383
      Nse4_C; Nse4 C-terminal
      pfam15412
      Location:144 → 187
      Nse4-Nse3_bdg; Binding domain of Nse4/EID3 to Nse3-MAGE
      cl14615
      Location:253 → 296
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22747645..22748967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8G2.2 GenPept UniProtKB/Swiss-Prot:Q4V8G2

    Gene LinkOut

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    Research Materials
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