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    Ip6k3 inositol hexakisphosphate kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688862, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ip6k3provided by RGD
    Official Full Name
    inositol hexakisphosphate kinase 3provided by RGD
    Primary source
    RGD:1584104
    See related
    Ensembl:ENSRNOG00000025883 AllianceGenome:RGD:1584104
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ihpk3
    Summary
    Predicted to enable inositol hexakisphosphate 6-kinase activity. Predicted to be involved in phosphatidylinositol metabolic process and protein phosphorylation. Predicted to act upstream of or within inositol phosphate biosynthetic process and locomotion. Predicted to be located in cytoplasm and nucleus. Orthologous to human IP6K3 (inositol hexakisphosphate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 83.6) and Heart (RPKM 21.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5225706..5247293, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5223863..5245443, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5733485..5754859, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 3 Neighboring gene uncharacterized LOC120098963 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 Neighboring gene uncharacterized LOC108353257 Neighboring gene LEM domain nuclear envelope protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel inositol hexakisphosphate kinase. Saiardi A, et al. J Biol Chem, 2001 Oct 19. PMID 11502751
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol hexakisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate kinase 3
    Names
    inositol hexaphosphate kinase 3
    XP_008771000.1
    XP_063135673.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5225706..5247293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279603.1 → XP_063135673.1  inositol hexakisphosphate kinase 3 isoform X2

    2. XM_008772778.4 → XP_008771000.1  inositol hexakisphosphate kinase 3 isoform X1

      UniProtKB/TrEMBL
      D4AEE6
      Related
      ENSRNOP00000033439.5
      Conserved Domains (1) summary
      pfam03770
      Location:193 → 395
      IPK; Inositol polyphosphate kinase

    RNA

    1. XR_005497460.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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