Anln anillin, actin binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anlnprovided by MGI
Official Full Name: anillin, actin binding proteinprovided by MGI
Primary source: MGI:MGI:1920174
See related: Ensembl:ENSMUSG00000036777 AllianceGenome:MGI:1920174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Scraps; 1110037A17Rik; 2900037I21Rik
Summary: Predicted to enable actin binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including brain and otocyst. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 8.2), CNS E11.5 (RPKM 7.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 8.93 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (22243305..22302132, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (22331214..22389211, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anillin governs mitotic rounding during early epidermal development.
Title: Anillin governs mitotic rounding during early epidermal development.
miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization.
Title: miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization.
High mobility group AT-hook 2 promotes tumorigenicity of pancreatic cancer cells via upregulating ANLN.
Title: High mobility group AT-hook 2 promotes tumorigenicity of pancreatic cancer cells via upregulating ANLN.
Anillin controls the levels of the GTPase RhoA, a known regulator of osteoclast cytoskeleton and resorption activity.
Title: Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin.
Loss of ANLN expression is associated with tumorigenesis in liver.
Title: The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
Knockdown of ANLN in liver cells blocks cytokinesis and inhibits development of liver tumors.
Title: Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.
data suggest that anillin is an essential intracellular component that maintains the integrity of asymmetric division in mouse oocytes.
Title: Anillin controls cleavage furrow formation in the course of asymmetric division during mouse oocyte maturation.
Anillin is excluded from the cortex of first polar body, enriched in the cytokinetic ring that severs the polar body from the oocyte. In meiosis II, anillin is enriched in a cortical stripe coincident with and overlying the meiotic spindle midzone.
Title: Anillin localization suggests distinct mechanisms of division plane specification in mouse oogenic meiosis I and II.
Results show that targeting of mDia2 to the cleavage furrow requires not only its binding to RhoA but also its diaphanous-inhibitory domain, and identify anillin as a novel mDia2 interaction partner.
Title: Rho and anillin-dependent control of mDia2 localization and function in cytokinesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH126306 (e-PCR)
- UniSTS:163014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in actomyosin contractile ring	ISO Inferred from Sequence Orthology more info
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anillin

Names: actin-binding protein anillin; anillin, actin binding protein (scraps homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404933.1 → NP_001391862.1 anillin isoform 1

Status: VALIDATED

Source sequence(s)

AC093926, AC159308
NM_028390.4 → NP_082666.2 anillin isoform 2

See identical proteins and their annotated locations for NP_082666.2

Status: VALIDATED

Source sequence(s)

AC093926, AC159308

Consensus CDS

CCDS22927.1

UniProtKB/Swiss-Prot

Q8BL79, Q8BLB3, Q8K298, Q8K2N0, Q9CUY0

Related

ENSMUSP00000045873.8, ENSMUST00000040912.9

Conserved Domains (4) summary

cd01263
Location:981 → 1107

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:984 → 1103

PH; PH domain

pfam08174
Location:797 → 950

Anillin; Cell division protein anillin

pfam16018
Location:141 → 227

Anillin_N; Anillin N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

22243305..22302132 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242594.2 → XP_011240896.1 anillin isoform X3

Conserved Domains (2) summary

cd01263
Location:504 → 630

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam08174
Location:302 → 455

Anillin; Cell division protein anillin
XM_006510582.5 → XP_006510645.1 anillin isoform X2

Conserved Domains (3) summary

PHA03307
Location:24 → 206

PHA03307; transcriptional regulator ICP4; Provisional

pfam08174
Location:797 → 950

Anillin; Cell division protein anillin

pfam16018
Location:141 → 227

Anillin_N; Anillin N-terminus