Zfp385a zinc finger protein 385A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp385aprovided by RGD
Official Full Name: zinc finger protein 385Aprovided by RGD
Primary source: RGD:1593784
See related: Ensembl:ENSRNOG00000036833 AllianceGenome:RGD:1593784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp385
Summary: Predicted to enable mRNA 3'-UTR binding activity and p53 binding activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; posttranscriptional regulation of gene expression; and regulation of signal transduction by p53 class mediator. Predicted to act upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and positive regulation of fat cell differentiation. Predicted to be located in dendrite. Predicted to be active in neuronal cell body and nucleus. Predicted to colocalize with chromatin. Orthologous to human ZNF385A (zinc finger protein 385A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 25.3), Brain (RPKM 22.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (136327393..136354017, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (134448914..134475548, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144939616..144966364, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Zfp385 (e-PCR), detects polymorphism
- UniSTS:468185

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within hemostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in mRNA localization resulting in post-transcriptional regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet alpha granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 385A

Names: zinc finger protein 385

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109470.2 → NP_001102940.1 zinc finger protein 385A isoform 2

See identical proteins and their annotated locations for NP_001102940.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K3Y0, A0A0G2KB91, A6KD07

Related

ENSRNOP00000075700.1, ENSRNOT00000083935.2

Conserved Domains (2) summary

sd00020
Location:203 → 225

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:261 → 285

zf-met; Zinc-finger of C2H2 type
NM_001135088.1 → NP_001128560.1 zinc finger protein 385A isoform 1

See identical proteins and their annotated locations for NP_001128560.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC166729

UniProtKB/TrEMBL

A0A0G2K3Y0, B2RYC6, F7FKR3

Related

ENSRNOP00000059042.3, ENSRNOT00000064261.3

Conserved Domains (2) summary

sd00020
Location:232 → 254

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:291 → 314

zf-met; Zinc-finger of C2H2 type
NM_001135089.1 → NP_001128561.1 zinc finger protein 385A isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K3Y0

Conserved Domains (2) summary

sd00020
Location:183 → 205

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:241 → 265

zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

136327393..136354017 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079900.2 → XP_038935828.1 zinc finger protein 385A isoform X2

UniProtKB/TrEMBL

A0A0G2K3Y0

Related

ENSRNOP00000072821.2

Conserved Domains (2) summary

sd00020
Location:219 → 241

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:277 → 301

zf-met; Zinc-finger of C2H2 type
XM_063264261.1 → XP_063120331.1 zinc finger protein 385A isoform X3
XM_039079899.2 → XP_038935827.1 zinc finger protein 385A isoform X1

UniProtKB/TrEMBL

A0A0G2K3Y0

Conserved Domains (2) summary

sd00020
Location:240 → 262

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:298 → 322

zf-met; Zinc-finger of C2H2 type
XM_039079901.2 → XP_038935829.1 zinc finger protein 385A isoform X4

UniProtKB/TrEMBL

A0A0G2K3Y0, A0A8I6AE41

Related

ENSRNOP00000091668.1

Conserved Domains (2) summary

sd00020
Location:164 → 186

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:222 → 246

zf-met; Zinc-finger of C2H2 type