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    Pnisr PNN interacting serine/arginine-rich [ Mus musculus (house mouse) ]

    Gene ID: 66625, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pnisrprovided by MGI
    Official Full Name
    PNN interacting serine/arginine-richprovided by MGI
    Primary source
    MGI:MGI:1913875
    See related
    Ensembl:ENSMUSG00000028248 AllianceGenome:MGI:1913875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pinsr; Sfrs18; Srsf18; 5730406M06Rik
    Summary
    Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nuclear speck and presynaptic active zone. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and nose. Orthologous to human PNISR (PNN interacting serine and arginine rich protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 36.1), CNS E14 (RPKM 33.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A3; 4 9.06 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21846621..21876475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21846657..21876475)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene cyclin C Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene coenzyme Q3 methyltransferase Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene failed axon connections homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. Cibi DM, et al. Elife, 2019 Jun 26. PMID 31241461, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arginine/serine-rich protein PNISR
    Names
    SRrp130
    serine/arginine-rich splicing factor 18
    serine/arginine-rich-splicing regulatory protein 130
    splicing factor, arginine/serine-rich 130
    splicing factor, arginine/serine-rich 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369189.1 → NP_001356118.1  arginine/serine-rich protein PNISR isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS89720.1
      UniProtKB/Swiss-Prot
      A2AJT4, Q9CS92
      UniProtKB/TrEMBL
      B2RUA1
      Related
      ENSMUSP00000095840.3, ENSMUST00000098238.9
      Conserved Domains (2) summary
      TIGR01642
      Location:643 → 750
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:223 → 380
      PNISR; Arginine/serine-rich protein PNISR

    2. NM_001369190.1 → NP_001356119.1  arginine/serine-rich protein PNISR isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Conserved Domains (2) summary
      TIGR01642
      Location:401 → 508
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:1 → 138
      PNISR; Arginine/serine-rich protein PNISR

    3. NM_001369191.1 → NP_001356120.1  arginine/serine-rich protein PNISR isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Conserved Domains (2) summary
      TIGR01642
      Location:401 → 508
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:1 → 138
      PNISR; Arginine/serine-rich protein PNISR

    4. NM_025669.2 → NP_079945.1  arginine/serine-rich protein PNISR isoform 1

      See identical proteins and their annotated locations for NP_079945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS51129.1
      UniProtKB/TrEMBL
      A2AJT5, B2RUA1
      Related
      ENSMUSP00000029911.6, ENSMUST00000029911.12
      Conserved Domains (2) summary
      TIGR01642
      Location:643 → 750
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:223 → 380
      PNISR; Arginine/serine-rich protein PNISR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      21846621..21876475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320353.3 → XP_017175842.1  arginine/serine-rich protein PNISR isoform X3

    2. XM_030253702.2 → XP_030109562.1  arginine/serine-rich protein PNISR isoform X2

      UniProtKB/TrEMBL
      B2RUA1
      Conserved Domains (2) summary
      TIGR01642
      Location:548 → 655
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:128 → 285
      PNISR; Arginine/serine-rich protein PNISR

    3. XM_006538184.5 → XP_006538247.1  arginine/serine-rich protein PNISR isoform X1

      See identical proteins and their annotated locations for XP_006538247.1

      UniProtKB/TrEMBL
      A2AJT5, B2RUA1
      Conserved Domains (2) summary
      TIGR01642
      Location:643 → 750
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam15996
      Location:223 → 380
      PNISR; Arginine/serine-rich protein PNISR
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJT4.1 GenPept UniProtKB/Swiss-Prot:A2AJT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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