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    mmp2 matrix metallopeptidase 2 [ Takifugu rubripes (torafugu) ]

    Gene ID: 653022, updated on 5-Mar-2024

    Summary

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    Gene symbol
    mmp2
    Gene description
    matrix metallopeptidase 2
    See related
    Ensembl:ENSTRUG00000010165
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Takifugu rubripes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu
    Also known as
    mmp-2; fgmmp-2
    Orthologs
    human zebrafish all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current fTakRub1.2 (GCF_901000725.2) 13 NC_042297.1 (9064457..9074903)
    101 previous assembly FUGU5 (GCF_000180615.1) 13 NC_018902.1 (5952853..5963249)

    Chromosome 13 - NC_042297.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115252094 Neighboring gene uncharacterized LOC115252093 Neighboring gene iroquois homeobox 6a Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene solute carrier family 6 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: Functional implications for adult neurogenesis. Sîrbulescu RF, et al. Mol Cell Neurosci, 2015 Sep. PMID 25827096
    2. Molecular cloning and expression of gelatinases (MMP-2 and MMP-9) in the pufferfish Takifugu rubripes. Tsukamoto H, et al. Comp Biochem Physiol B Biochem Mol Biol, 2007 Nov. PMID 17644016

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that MMP-2 is primarily involved in regulation of the activity of stem/progenitor cells that give rise to new granule neurons.
      Title: Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: Functional implications for adult neurogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    72 kDa type IV collagenase
    Names
    matrix metalloproteinase-2
    NP_001032958.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037869.1 → NP_001032958.1  72 kDa type IV collagenase precursor

      See identical proteins and their annotated locations for NP_001032958.1

      Status: PROVISIONAL

      Source sequence(s)
      AB193483
      UniProtKB/TrEMBL
      A0A674P1U4, H2TLN6, Q4JF84
      Related
      ENSTRUP00000076684.1, ENSTRUT00000082228.1
      Conserved Domains (5) summary
      smart00059
      Location:342 → 390
      FN2; Fibronectin type 2 domain
      cd00094
      Location:464 → 658
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:119 → 446
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:119 → 446
      Peptidase_M10; Matrixin
      pfam01471
      Location:70 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Takifugu rubripes Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fTakRub1.2 Primary Assembly

    Genomic

    1. NC_042297.1 Reference fTakRub1.2 Primary Assembly

      Range
      9064457..9074903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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