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1. |
Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro |
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2. |
neuronal guanine nucleotide exchange factor, intersectin-1L, activates the GTPase Cdc42, which in turn provides de novo actin filaments that are important for calcium-regulated exocytosis in PC12 cells |
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3. |
Produces signals that are essential for the neurite outgrowth of PC12 cells and cerebellar granule neurons. |
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4. |
Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation. |
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5. |
These data describe a novel role for Rho in coordinating signaling by Rac and Cdc42. |
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6. |
Data suggest that Cdc42 activation is crucial for the regulation of actin polymerization in carcinoma cells, and required for both EGF-stimulated protrusion and cell motility independently of effects on Rac. |
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7. |
Results show that phenylalanine reduced the number of dendrites and dendritic spines in cultured neurons, and that phenylalanine down-regulated Rac1, Cdc42, and RhoA mRNA and protein expression. |
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8. |
the Cdc42/PAK3 is a key module in dendritic spine formation and synaptic plasticity |
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9. |
Inhibition of cdc42 in nigral neurons blocked medial forebrain bundle axotomy-induced activation (phosphorylation) of MAP kinase kinase 4 and c-Jun, resulting in attenuation of substantia nigra pars compacta neuronal death. |
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10. |
Interactions among IQGAP1, Cdc42, and beta-catenin are crucial to the regulation of Sertoli-germ cell, but not Sertoli-Sertoli cell, adherens junction dynamics in the seminiferous epithelium. |
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11. |
FGF2 endocytosis requires syndecan-4 clustering-dependent activation of Rac1 and the intact CDC42-dependent macropinocytic pathway |
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12. |
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity |
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13. |
differences in expression of rho GTPases between different regions of the hippocampus, and between the molecular and granular layers in the cerebellum. |
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14. |
PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1 |
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15. |
Study concludes that Scrib plays a key role in the establishment of cell polarity during migration; by interacting with betaPIX, Scrib controls localization and activation of the small GTPase Cdc42 and regulates Cdc42-dependent polarization pathways. |
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16. |
Cdc42-induced targeting at cell-cell contacts is dependent on CEACAM1 |
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17. |
role of the Rac/Cdc42-IQGAP1 system in the dynamic organization and maintenance of the E-cadherin-based adherens junctions |
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18. |
Cdc42 has profound effects on the recruitment of dynein to COPI vesicles. Cdc42, when bound to coatomer, inhibits dynein binding to COPI vesicles whereas preventing the coatomer-Cdc42 interaction stimulates dynein binding. |
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19. |
active state of Cdc42 is important in upregulation of phospholipase D1 activity which is responsible for the increase of neurite outgrowth |
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20. |
These findings strongly suggest that Cdc42 serves as an upstream activator and modulates JNK-mediated apoptosis machinery in vivo, which ultimately results in neuronal apoptosis via nuclear and non-nuclear pathways. |
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21. |
involved in extracellular matrix-basolateral membrane interactions |
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22. |
role in cyclooxygenase-2 gene expression |
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23. |
Activation of Rac1 and Cdc42 was caused by both guanine nucleotide exchange factors and GAPs, and was important for neurite extension. |
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24. |
Findings suggest that Rin-mediated neurite outgrowth requires not only Rac/Cdc42 activation but also Rin-calmodulin association, and that Rin is involved in calcium/CaM-mediated neuronal signaling. |
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25. |
Activation of Rac-1 and Cdc42 stabilizes microvascular endothelial barrier functions in vitro and in vivo, likely by increasing the junction-associated actin cytoskeleton. |