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    PCCA propionyl-CoA carboxylase subunit alpha [ Bos taurus (cattle) ]

    Gene ID: 614302, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PCCAprovided by VGNC
    Official Full Name
    propionyl-CoA carboxylase subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:32613
    See related
    Ensembl:ENSBTAG00000010672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (76754289..77174973)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene Zic family member 5 Neighboring gene asparagine synthetase [glutamine-hydrolyzing]-like Neighboring gene Zic family member 2 Neighboring gene microRNA mir-2285aq-2 Neighboring gene U6 spliceosomal RNA Neighboring gene gamma-glutamylamine cyclotransferase Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142931

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables propionyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    propionyl-CoA carboxylase alpha chain, mitochondrial
    Names
    propionyl CoA carboxylase, alpha polypeptide
    propionyl Coenzyme A carboxylase, alpha polypeptide
    propionyl-CoA carboxylase alpha subunit
    NP_001076978.1
    XP_024855721.1
    XP_024855722.1
    XP_024855723.1
    XP_059748095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083509.1 → NP_001076978.1  propionyl-CoA carboxylase alpha chain, mitochondrial

      See identical proteins and their annotated locations for NP_001076978.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123876
      UniProtKB/TrEMBL
      A0A3Q1MM69, A4FV90, F6QNC4
      Related
      ENSBTAP00000014120.6, ENSBTAT00000014120.6
      Conserved Domains (5) summary
      cd06850
      Location:675 → 740
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      smart00878
      Location:397 → 504
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      COG4770
      Location:63 → 741
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
      pfam00289
      Location:63 → 171
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02786
      Location:176 → 383
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      76754289..77174973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892112.1 → XP_059748095.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4

      Related
      ENSBTAP00000075871.1, ENSBTAT00000111267.1

    2. XM_024999954.2 → XP_024855722.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MM69
      Related
      ENSBTAP00000060748.2, ENSBTAT00000073154.2
      Conserved Domains (1) summary
      COG4770
      Location:63 → 694
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

    3. XM_024999953.2 → XP_024855721.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LYL5
      Related
      ENSBTAP00000062360.2, ENSBTAT00000081754.2
      Conserved Domains (1) summary
      COG4770
      Location:63 → 730
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

    4. XM_024999955.2 → XP_024855723.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LTS4, A0A3Q1LYL5
      Related
      ENSBTAP00000088015.1, ENSBTAT00000094365.1
      Conserved Domains (1) summary
      COG4770
      Location:63 → 683
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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