dtx4a deltex 4, E3 ubiquitin ligase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dtx4aprovided by ZNC
Official Full Name: deltex 4, E3 ubiquitin ligase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-160728-59
See related: Ensembl:ENSDARG00000076302 AllianceGenome:ZFIN:ZDB-GENE-160728-59
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dtx1; si:ch211-119e14.2
Summary: Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (18558269..18601206, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (18306002..18348939, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results demonstrated that Dtx1 is regulated by Notch-Hairy/E(Spl) signaling and is a major factor specifically regulating neural differentiation.
Title: Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase DTX4a

Names: deltex1

NP_001120780.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127308.1 → NP_001120780.1 E3 ubiquitin-protein ligase DTX4a

See identical proteins and their annotated locations for NP_001120780.1

Status: PROVISIONAL

Source sequence(s)

DQ497599

UniProtKB/TrEMBL

B2KJ26

Related

ENSDARP00000102662.1, ENSDART00000111636.4

Conserved Domains (5) summary

smart00678
Location:8 → 86

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd09633
Location:563 → 695

Deltex_C; Domain found at the C-terminus of deltex-like

cd00162
Location:493 → 556

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam02825
Location:90 → 144

WWE; WWE domain

pfam15374
Location:330 → 472

CCDC71L; Coiled-coil domain-containing protein 71L