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    Get3 guided entry of tail-anchored proteins factor 3, ATPase [ Mus musculus (house mouse) ]

    Gene ID: 56495, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Get3provided by MGI
    Official Full Name
    guided entry of tail-anchored proteins factor 3, ATPaseprovided by MGI
    Primary source
    MGI:MGI:1928379
    See related
    Ensembl:ENSMUSG00000052456 AllianceGenome:MGI:1928379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ArsA; Asna1; 1810048H22Rik
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of GET complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and vibrissa. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 83.4), testis adult (RPKM 69.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C3; 8 41.48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85744558..85751916, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85017929..85025287, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3789 Neighboring gene hook microtubule tethering protein 2 Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene telomerase RNA component interacting RNase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene transportin 2 (importin 3, karyopherin beta 2b) Neighboring gene predicted gene, 25506

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the mouse Asna1 gene results in embryonic lethality. Mukhopadhyay R, et al. FEBS Lett, 2006 Jul 10. PMID 16797549
    2. Genomic organization and chromosomal localization of the Asna1 gene, a mouse homologue of a bacterial arsenic-translocating ATPase gene. Bhattacharjee H, et al. Gene, 2001 Jul 11. PMID 11470536
    3. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Norlin S, et al. Diabetes, 2016 Jan. PMID 26438609
    4. Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. Favaloro V, et al. J Cell Sci, 2008 Jun 1. PMID 18477612, Free PMC Article
    5. Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. Vogl C, et al. EMBO J, 2016 Dec 1. PMID 27458190, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings support a role for the Asna1 ATPase activity in ensuring the survival of pancreatic multipotent progenitor cells , possibly by counteracting p53-mediated apoptosis.
      Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
    2. Asna1 ensures retrograde transport and ER and insulin homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that rapidly progresses to overt diabetes.
      Title: Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport.
    3. These findings indicate that Asna1 plays a crucial role during early embryonic development.
      Title: Targeted disruption of the mouse Asna1 gene results in embryonic lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GET complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATPase GET3
    Names
    ATPase Asna1
    arsenical pump-driving ATPase
    arsenite-stimulated ATPase
    arsenite-translocating ATPase
    NP_001344131.1
    NP_001344132.1
    NP_062626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357202.1 → NP_001344131.1  ATPase GET3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q8VEI6
      Conserved Domains (1) summary
      cl38936
      Location:1 → 217
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001357203.1 → NP_001344132.1  ATPase GET3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q8VEI6
      Conserved Domains (1) summary
      cl38936
      Location:1 → 217
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_019652.2 → NP_062626.1  ATPase GET3 isoform 1

      See identical proteins and their annotated locations for NP_062626.1

      Status: VALIDATED

      Source sequence(s)
      BC083335, BY230823, BY631769
      Consensus CDS
      CCDS40417.1
      UniProtKB/Swiss-Prot
      O54984, Q3TAQ4
      Related
      ENSMUSP00000065337.9, ENSMUST00000064314.10
      Conserved Domains (1) summary
      pfam02374
      Location:37 → 340
      ArsA_ATPase; Anion-transporting ATPase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85744558..85751916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54984.2 GenPept UniProtKB/Swiss-Prot:O54984

    Gene LinkOut

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