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    st6galnac1.1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 564336, updated on 14-Apr-2024

    Summary

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    Official Symbol
    st6galnac1.1provided by ZNC
    Official Full Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-160
    See related
    Ensembl:ENSDARG00000043814 AllianceGenome:ZFIN:ZDB-GENE-041014-160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    siat3; st6GalNAc I; si:ch211-51n14.1
    Summary
    Predicted to enable sialyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain; gill; integument; liver; and pleuroperitoneal region. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20667304..20686390)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (20556210..20563750)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene gastric inhibitory polypeptide Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 2 Neighboring gene CASK interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
    2. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1
    Names
    alpha 2,6-sialyltransferase ST6GalNAc I
    st6galnac1-r1
    NP_001314970.1
    XP_021335804.1
    XP_021335805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328041.1 → NP_001314970.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1

      Status: VALIDATED

      Source sequence(s)
      CR385044
      UniProtKB/TrEMBL
      A0A8M9QEC7, Q5P990
      Related
      ENSDARP00000115490.2, ENSDART00000146762.3
      Conserved Domains (1) summary
      pfam00777
      Location:120 → 404
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      20667304..20686390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480129.1 → XP_021335804.1  ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:120 → 404
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_021480130.1 → XP_021335805.1  ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:120 → 404
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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