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    garnl3 GTPase activating Rap/RanGAP domain like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 560594, updated on 27-Mar-2024

    Summary

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    Official Symbol
    garnl3provided by ZNC
    Official Full Name
    GTPase activating Rap/RanGAP domain like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-61
    See related
    Ensembl:ENSDARG00000060631 AllianceGenome:ZFIN:ZDB-GENE-060526-61
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-46k8.1; si:ch211-182d3.1
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within regulation of small GTPase mediated signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human GARNL3 (GTPase activating Rap/RanGAP domain like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33352656..33461589, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (32755520..32861250, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108190093 Neighboring gene prostaglandin E synthase Neighboring gene si:dkey-34e4.1 Neighboring gene membrane-spanning 4-domains, subfamily A, member 17C.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating Rap/Ran-GAP domain-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128527.1 → NP_001121999.1  GTPase-activating Rap/Ran-GAP domain-like protein 3

      See identical proteins and their annotated locations for NP_001121999.1

      Status: PROVISIONAL

      Source sequence(s)
      BX005029
      UniProtKB/Swiss-Prot
      A5PF44
      Related
      ENSDARP00000080071.5, ENSDART00000085636.6
      Conserved Domains (2) summary
      pfam00780
      Location:502 → 809
      CNH; CNH domain
      pfam02145
      Location:230 → 408
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      33352656..33461589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301519.3 → XP_009299794.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B9N6
      Conserved Domains (2) summary
      pfam00780
      Location:502 → 818
      CNH; CNH domain
      pfam02145
      Location:230 → 408
      Rap_GAP; Rap/ran-GAP

    2. XM_005171887.4 → XP_005171944.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BJ60
      Conserved Domains (2) summary
      pfam00780
      Location:502 → 818
      CNH; CNH domain
      pfam02145
      Location:230 → 408
      Rap_GAP; Rap/ran-GAP

    3. XM_009301517.3 → XP_009299792.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AZN5
      Conserved Domains (2) summary
      pfam00780
      Location:508 → 824
      CNH; CNH domain
      pfam02145
      Location:230 → 408
      Rap_GAP; Rap/ran-GAP

    4. XM_009301515.3 → XP_009299790.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ASH8
      Conserved Domains (2) summary
      pfam00780
      Location:508 → 824
      CNH; CNH domain
      pfam02145
      Location:230 → 408
      Rap_GAP; Rap/ran-GAP

    5. XM_009301518.3 → XP_009299793.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M3ASD2
      Conserved Domains (2) summary
      pfam00780
      Location:485 → 801
      CNH; CNH domain
      pfam02145
      Location:207 → 385
      Rap_GAP; Rap/ran-GAP

    6. XM_009301516.3 → XP_009299791.1  GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3B2J1
      Conserved Domains (2) summary
      pfam00780
      Location:491 → 807
      CNH; CNH domain
      pfam02145
      Location:213 → 391
      Rap_GAP; Rap/ran-GAP

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394588.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      64151..163858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5PF44.1 GenPept UniProtKB/Swiss-Prot:A5PF44

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