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    exoc4 exocyst complex component 4 [ Danio rerio (zebrafish) ]

    Gene ID: 559866, updated on 27-Mar-2024

    Summary

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    Official Symbol
    exoc4provided by ZNC
    Official Full Name
    exocyst complex component 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-112
    See related
    Ensembl:ENSDARG00000004336 AllianceGenome:ZFIN:ZDB-GENE-041210-112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:rp71-18a24.2; si:ch211-92l17.2
    Summary
    Predicted to be involved in Golgi to plasma membrane transport; chemical synaptic transmission; and exocytosis. Predicted to act upstream of or within protein transport and vesicle docking involved in exocytosis. Predicted to be part of exocyst. Predicted to be active in growth cone membrane and synapse. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15605844..15816410)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15607073..15817655)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910431 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3a Neighboring gene si:ch211-92l17.1 Neighboring gene leucine-rich repeats and guanylate kinase domain containing Neighboring gene collagen type VII alpha 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The exocyst is required for photoreceptor ciliogenesis and retinal development. Lobo GP, et al. J Biol Chem, 2017 Sep 8. PMID 28729419, Free PMC Article
    2. Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis. Fulmer D, et al. Circulation, 2019 Oct 15. PMID 31387361, Free PMC Article
    3. Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Madakashira BP, et al. Genes (Basel), 2021 Jul 16. PMID 34356097, Free PMC Article
    4. Brain Proteome and Behavioural Analysis in Wild Type, BDNF(+/-) and BDNF(-/-) Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. Maffioli E, et al. Int J Mol Sci, 2022 May 17. PMID 35628418, Free PMC Article
    5. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle tethering involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in growth cone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 4
    Names
    exocyst complex component Sec8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030134.2 → NP_001025305.1  exocyst complex component 4

      Status: PROVISIONAL

      Source sequence(s)
      BX470240, BX649386
      UniProtKB/TrEMBL
      A0A8M1N783, Q5TYY2
      Related
      ENSDARP00000020340.7, ENSDART00000021384.9
      Conserved Domains (1) summary
      pfam04048
      Location:55 → 140
      Sec8_exocyst; Sec8 exocyst complex component specific domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      15605844..15816410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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