socs5b suppressor of cytokine signaling 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: socs5bprovided by ZNC
Official Full Name: suppressor of cytokine signaling 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080722-18
See related: Ensembl:ENSDARG00000062745 AllianceGenome:ZFIN:ZDB-GENE-080722-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: socs5l
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of phosphatidylinositol 3-kinase complex. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (8604621..8625298)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (8272649..8291596)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z46765 (e-PCR), detects polymorphism
- UniSTS:238596

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: suppressor of cytokine signaling 5; suppressor of cytokine signaling 5b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113797.1 → NP_001107269.1 suppressor of cytokine signaling 5b

See identical proteins and their annotated locations for NP_001107269.1

Status: PROVISIONAL

Source sequence(s)

EF195762

UniProtKB/TrEMBL

A0A2R8QTG7, B0EVP6, F6P293

Related

ENSDARP00000085530.4, ENSDART00000091097.6

Conserved Domains (3) summary

cd03739
Location:499 → 555

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:133 → 187

SOCS; Suppressor of cytokine signalling

cl15255
Location:390 → 490

SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

8604621..8625298

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156601.4 → XP_005156658.1 suppressor of cytokine signaling 5 isoform X1

UniProtKB/TrEMBL

A0A8M2B3H1

Conserved Domains (3) summary

cd03739
Location:540 → 596

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:174 → 228

SOCS; Suppressor of cytokine signalling

cl15255
Location:431 → 531

SH2; Src homology 2 (SH2) domain