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    asb6 ankyrin repeat and SOCS box containing 6 [ Danio rerio (zebrafish) ]

    Gene ID: 553600, updated on 27-Mar-2024

    Summary

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    Official Symbol
    asb6provided by ZNC
    Official Full Name
    ankyrin repeat and SOCS box containing 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-338
    See related
    Ensembl:ENSDARG00000007125 AllianceGenome:ZFIN:ZDB-GENE-050522-338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110231
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (6903327..6918730, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (6859779..6875173, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-255g12.8 Neighboring gene neurofilament light chain b Neighboring gene WD repeat domain 13 Neighboring gene si:ch211-255g12.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110231

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020576.2 → NP_001018412.1  ankyrin repeat and SOCS box protein 6

      See identical proteins and their annotated locations for NP_001018412.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095208
      UniProtKB/TrEMBL
      Q503S0
      Related
      ENSDARP00000018746.6, ENSDART00000014915.8
      Conserved Domains (5) summary
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      pfam12796
      Location:100 → 199
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:66 → 116
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      6903327..6918730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478258.1 → XP_021333933.1  ankyrin repeat and SOCS box protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    2. XM_005166693.4 → XP_005166750.1  ankyrin repeat and SOCS box protein 6 isoform X2

      See identical proteins and their annotated locations for XP_005166750.1

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    3. XM_017357334.2 → XP_017212823.1  ankyrin repeat and SOCS box protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    4. XM_005166692.4 → XP_005166749.1  ankyrin repeat and SOCS box protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE50
      Conserved Domains (5) summary
      cd00204
      Location:119 → 229
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:396 → 439
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      pfam12796
      Location:122 → 221
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:88 → 138
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:121 → 148
      ANK; ANK repeat [structural motif]

    5. XM_021478259.1 → XP_021333934.1  ankyrin repeat and SOCS box protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    6. XM_005166695.4 → XP_005166752.1  ankyrin repeat and SOCS box protein 6 isoform X2

      See identical proteins and their annotated locations for XP_005166752.1

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]

    7. XM_005166694.4 → XP_005166751.1  ankyrin repeat and SOCS box protein 6 isoform X2

      See identical proteins and their annotated locations for XP_005166751.1

      UniProtKB/TrEMBL
      A0A8M2BE57, B0R1B6
      Conserved Domains (4) summary
      PHA02884
      Location:49 → 138
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:97 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:374 → 417
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:99 → 126
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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