U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    nsmce4a NSE4 homolog A, SMC5-SMC6 complex component [ Danio rerio (zebrafish) ]

    Gene ID: 553544, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nsmce4aprovided by ZNC
    Official Full Name
    NSE4 homolog A, SMC5-SMC6 complex componentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-111
    See related
    Ensembl:ENSDARG00000024311 AllianceGenome:ZFIN:ZDB-GENE-050522-111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:109897; CH73-19J14.1
    Summary
    Predicted to be involved in DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; head; immature eye; optic tectum; and pectoral fin bud. Orthologous to several human genes including NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (28784430..28796818)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (28655409..28666187)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene prominin 2 Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene lymphocyte antigen 6 family member pge

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC109897

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    non-structural maintenance of chromosomes element 4 homolog A
    Names
    NSE4 homolog, SMC5-SMC6 complex component A
    non-SMC element 4 homolog A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020523.1 → NP_001018359.1  non-structural maintenance of chromosomes element 4 homolog A

      See identical proteins and their annotated locations for NP_001018359.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095037
      UniProtKB/TrEMBL
      Q504G2
      Related
      ENSDARP00000029924.6, ENSDART00000039028.8
      Conserved Domains (2) summary
      pfam08743
      Location:259 → 344
      Nse4_C; Nse4 C-terminal
      pfam15412
      Location:109 → 155
      Nse4-Nse3_bdg; Binding domain of Nse4/EID3 to Nse3-MAGE

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      28784430..28796818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480579.1 → XP_021336254.1  non-structural maintenance of chromosomes element 4 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFD5
      Conserved Domains (2) summary
      pfam08743
      Location:259 → 344
      Nse4_C; Nse4 C-terminal
      pfam15412
      Location:109 → 159
      Nse4-Nse3_bdg; Binding domain of Nse4/EID3 to Nse3-MAGE
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous