sostdc1a sclerostin domain containing 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sostdc1aprovided by ZNC
Official Full Name: sclerostin domain containing 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-64
See related: Ensembl:ENSDARG00000068892 AllianceGenome:ZFIN:ZDB-GENE-050417-64
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110293
Summary: Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway and negative regulation of Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SOSTDC1 (sclerostin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (34562194..34567365, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (34704225..34709396, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sclerostin domain-containing protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017598.2 → NP_001017598.2 sclerostin domain-containing protein 1a precursor

Status: VALIDATED

Source sequence(s)

EH592789, EH605481, FP102309

UniProtKB/TrEMBL

A0A8M1N5B8, A7MCD1

Related

ENSDARP00000090566.3, ENSDART00000099793.4

Conserved Domains (1) summary

cl21545
Location:9 → 189

GHB_like; Glycoprotein hormone beta chain homologues