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    KPNA1 karyopherin subunit alpha 1 [ Bos taurus (cattle) ]

    Gene ID: 539679, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KPNA1provided by VGNC
    Official Full Name
    karyopherin subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:30700
    See related
    BGD:BT28818; Ensembl:ENSBTAG00000011143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (66873211..66944350, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 162 member A Neighboring gene ribosomal protein S15a pseudogene Neighboring gene WD repeat domain 5B Neighboring gene U6 spliceosomal RNA Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene poly(ADP-ribose) polymerase family member 14 Neighboring gene HSPB1 associated protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7. Joubert DA, et al. J Virol, 2014 Feb. PMID 24257609, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7.
      Title: Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152064

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin subunit alpha-5
    Names
    importin subunit alpha-1
    karyopherin alpha 1 (importin alpha 5)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081733.2 → NP_001075202.1  importin subunit alpha-5

      See identical proteins and their annotated locations for NP_001075202.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133509
      UniProtKB/Swiss-Prot
      A2VE08
      UniProtKB/TrEMBL
      A0A3Q1LXF0
      Related
      ENSBTAP00000014799.5, ENSBTAT00000014799.6
      Conserved Domains (2) summary
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]
      cl25709
      Location:33 → 516
      Arm_3; Atypical Arm repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66873211..66944350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015471547.3 → XP_015327033.1  importin subunit alpha-5 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LXF0
      Conserved Domains (5) summary
      cd00020
      Location:133 → 254
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:19 → 117
      IBB; Importin beta binding domain
      pfam13646
      Location:141 → 250
      HEAT_2; HEAT repeats
      pfam16186
      Location:479 → 523
      Arm_3; Atypical Arm repeat
      sd00043
      Location:141 → 167
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VE08.1 GenPept UniProtKB/Swiss-Prot:A2VE08

    Gene LinkOut

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