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    NLRP3 NLR family pyrin domain containing 3 [ Bos taurus (cattle) ]

    Gene ID: 538639, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NLRP3provided by VGNC
    Official Full Name
    NLR family pyrin domain containing 3provided by VGNC
    Primary source
    VGNC:VGNC:32117
    See related
    BGD:BT11736; Ensembl:ENSBTAG00000001273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NLRP3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (40661404..40710827)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2-like Neighboring gene U6 spliceosomal RNA Neighboring gene olfactory receptor family 2 subfamily H member 10 Neighboring gene olfactory receptor family 2 subfamily B member 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains. De Biase D, et al. J Cell Physiol, 2020 Jun. PMID 31903559
    2. The Potential Therapeutic Role of miR-223 in Bovine Endometritis by Targeting the NLRP3 Inflammasome. Zhao G, et al. Front Immunol, 2018. PMID 30186287, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Necrotic Cell Death and Inflammasome NLRP3 Activity in Mycobacterium bovis-Infected Bovine Macrophages.
      Title: Necrotic Cell Death and Inflammasome NLRP3 Activity in Mycobacterium bovis-Infected Bovine Macrophages.
    2. Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.
      Title: Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.
    3. study highlights that miR-223 serves both to constrain the level of NLRP3 activation and to act as a protective factor in the inflammatory response and thus provides a future novel therapeutic modality for active flares in cow endometritis and other inflammatory diseases.
      Title: The Potential Therapeutic Role of miR-223 in Bovine Endometritis by Targeting the NLRP3 Inflammasome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159873

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NLRP3 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102219.1 → NP_001095689.1  NACHT, LRR and PYD domains-containing protein 3

      See identical proteins and their annotated locations for NP_001095689.1

      Status: PROVISIONAL

      Source sequence(s)
      BC147936
      UniProtKB/Swiss-Prot
      A6QLE5
      Related
      ENSBTAP00000001675.5, ENSBTAT00000001675.6
      Conserved Domains (6) summary
      smart00368
      Location:963 → 990
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:573 → 948
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:738 → 766
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:217 → 386
      NACHT; NACHT domain
      pfam14484
      Location:135 → 206
      FISNA; Fish-specific NACHT associated domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40661404..40710827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010807177.4 → XP_010805479.1  NACHT, LRR and PYD domains-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_010805479.1

      UniProtKB/Swiss-Prot
      A6QLE5
      Conserved Domains (6) summary
      smart00368
      Location:963 → 990
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:573 → 948
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:738 → 766
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:217 → 386
      NACHT; NACHT domain
      pfam14484
      Location:135 → 206
      FISNA; Fish-specific NACHT associated domain

    2. XM_059888311.1 → XP_059744294.1  NACHT, LRR and PYD domains-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6QLE5

    3. XM_059888312.1 → XP_059744295.1  NACHT, LRR and PYD domains-containing protein 3 isoform X2

      Related
      ENSBTAP00000103656.1, ENSBTAT00000089012.1

    4. XM_059888313.1 → XP_059744296.1  NACHT, LRR and PYD domains-containing protein 3 isoform X3

    5. XM_059888315.1 → XP_059744298.1  NACHT, LRR and PYD domains-containing protein 3 isoform X4

    6. XM_059888316.1 → XP_059744299.1  NACHT, LRR and PYD domains-containing protein 3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QLE5.1 GenPept UniProtKB/Swiss-Prot:A6QLE5

    Gene LinkOut

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