U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CG3021 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53546, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG3021provided by FlyBase
    Primary source
    FLYBASE:FBgn0040337
    Locus tag
    Dmel_CG3021
    See related
    AllianceGenome:FB:FBgn0040337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-1Ed; Dmel\CG3021; E; EG:BACR7A4.8
    Summary
    Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    1E1-1E1; 1-0.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1026791..1028290)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (920824..922323)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 45 Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p21

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. Zachar Z, et al. Mol Cell Biol, 1987 Jul. PMID 3039348, Free PMC Article
    2. A comparative genomic analysis of two distant diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. Bolshakov VN, et al. Genome Res, 2002 Jan. PMID 11779831, Free PMC Article
    3. Circadian regulation of gene expression systems in the Drosophila head. Claridge-Chang A, et al. Neuron, 2001 Nov 20. PMID 11719206
    4. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Benos PV, et al. Genome Res, 2001 May. PMID 11337470, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-5-taurinomethyluridine 2-sulfurtransferase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG3021-PA
    transcription unit E
    NP_652639.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1026791..1028290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144382.4 → NP_652639.1  uncharacterized protein Dmel_CG3021 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960Y5, Q9W5B6
      UniProtKB/TrEMBL
      Q9U1L1
      Related
      FBpp0070168
      Conserved Domains (2) summary
      cd01998
      Location:14 → 366
      tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
      pfam03054
      Location:14 → 366
      tRNA_Me_trans; tRNA methyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1L1 Q9U1L1
    Q9W5B6.3 Q9W5B6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous