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    GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 [ Bos taurus (cattle) ]

    Gene ID: 523515, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GABRA5provided by VGNC
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit alpha5provided by VGNC
    Primary source
    VGNC:VGNC:29194
    See related
    BGD:BT12028; Ensembl:ENSBTAG00000003392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GABRA5 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (4267282..4359565)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene gamma-aminobutyric acid type A receptor subunit beta3 Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC139683

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables benzodiazepine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-5
    Names
    GABA(A) receptor subunit alpha-5
    gamma-aminobutyric acid (GABA) A receptor, alpha 5
    gamma-aminobutyric acid type A receptor alpha5 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075844.1 → NP_001069312.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

      See identical proteins and their annotated locations for NP_001069312.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123418
      UniProtKB/Swiss-Prot
      Q08E50
      Related
      ENSBTAP00000004397.3, ENSBTAT00000004397.4
      Conserved Domains (3) summary
      TIGR00860
      Location:51 → 448
      LIC; Cation transporter family protein
      pfam02931
      Location:50 → 257
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:264 → 445
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      4267282..4359565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221734.5 → XP_005221791.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_005221791.1

      UniProtKB/Swiss-Prot
      Q08E50
      Conserved Domains (3) summary
      TIGR00860
      Location:51 → 448
      LIC; Cation transporter family protein
      pfam02931
      Location:50 → 257
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:264 → 445
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. XM_005221733.5 → XP_005221790.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_005221790.1

      UniProtKB/Swiss-Prot
      Q08E50
      Conserved Domains (3) summary
      TIGR00860
      Location:51 → 448
      LIC; Cation transporter family protein
      pfam02931
      Location:50 → 257
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:264 → 445
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. XM_005221731.5 → XP_005221788.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_005221788.1

      UniProtKB/Swiss-Prot
      Q08E50
      Conserved Domains (3) summary
      TIGR00860
      Location:51 → 448
      LIC; Cation transporter family protein
      pfam02931
      Location:50 → 257
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:264 → 445
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08E50.1 GenPept UniProtKB/Swiss-Prot:Q08E50

    Gene LinkOut

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