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    ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 [ Bos taurus (cattle) ]

    Gene ID: 522521, updated on 31-Mar-2024

    Summary

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    Official Symbol
    ARHGEF18provided by VGNC
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 18provided by VGNC
    Primary source
    VGNC:VGNC:106426
    See related
    BGD:BT22530; Ensembl:ENSBTAG00000040507
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (16245839..16345940)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3-like 3 Neighboring gene insulin receptor Neighboring gene uncharacterized LOC112447347 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene testis expressed 45

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGEF18 can promote BVDV NS5B activation of the host NF-kappaB signaling pathway by combining with the NS5B-palm domain.
      Title: ARHGEF18 can promote BVDV NS5B activation of the host NF-κB signaling pathway by combining with the NS5B-palm domain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 18
    Names
    Rho/Rac guanine nucleotide exchange factor (GEF) 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16245839..16345940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806870.4 → XP_010805172.1  rho guanine nucleotide exchange factor 18 isoform X2

      See identical proteins and their annotated locations for XP_010805172.1

      UniProtKB/TrEMBL
      E1B9G8
      Conserved Domains (4) summary
      cd00160
      Location:455 → 649
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:689 → 804
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:735 → 793
      PH; PH domain
      pfam02050
      Location:1029 → 1135
      FliJ; Flagellar FliJ protein

    2. XM_010806868.4 → XP_010805170.1  rho guanine nucleotide exchange factor 18 isoform X2

      See identical proteins and their annotated locations for XP_010805170.1

      UniProtKB/TrEMBL
      E1B9G8
      Related
      ENSBTAP00000014311.5, ENSBTAT00000014311.6
      Conserved Domains (4) summary
      cd00160
      Location:455 → 649
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:689 → 804
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:735 → 793
      PH; PH domain
      pfam02050
      Location:1029 → 1135
      FliJ; Flagellar FliJ protein

    3. XM_010806872.4 → XP_010805174.1  rho guanine nucleotide exchange factor 18 isoform X2

      See identical proteins and their annotated locations for XP_010805174.1

      UniProtKB/TrEMBL
      E1B9G8
      Conserved Domains (4) summary
      cd00160
      Location:455 → 649
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:689 → 804
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:735 → 793
      PH; PH domain
      pfam02050
      Location:1029 → 1135
      FliJ; Flagellar FliJ protein

    4. XM_010806871.4 → XP_010805173.1  rho guanine nucleotide exchange factor 18 isoform X2

      See identical proteins and their annotated locations for XP_010805173.1

      UniProtKB/TrEMBL
      E1B9G8
      Conserved Domains (4) summary
      cd00160
      Location:455 → 649
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:689 → 804
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:735 → 793
      PH; PH domain
      pfam02050
      Location:1029 → 1135
      FliJ; Flagellar FliJ protein

    5. XM_059888596.1 → XP_059744579.1  rho guanine nucleotide exchange factor 18 isoform X1

    6. XM_010806873.4 → XP_010805175.1  rho guanine nucleotide exchange factor 18 isoform X3

      See identical proteins and their annotated locations for XP_010805175.1

      Conserved Domains (4) summary
      PRK13729
      Location:718 → 868
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 451
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      cl25732
      Location:652 → 779
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_059888597.1 → XP_059744580.1  rho guanine nucleotide exchange factor 18 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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