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1: ZBTB7A zinc finger and BTB domain containing 7A [ Homo sapiens ]

GeneID: 51341 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
ZBTB7Aprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Aprovided by HGNC
Primary Source
HGNC:18078
See related
Ensembl:ENSG00000178951; HPRD:10433; MIM:605878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRF; FBI1; FBI-1; ZBTB7; ZNF857A; pokemon; MGC99631; DKFZp547O146; ZBTB7A

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. The ZBTB7A protein co-localizes with either eukaryotic translation initiator protein 1A or isoform at the nuclear periplasm.
PubMed 2. Pokemon had some clinical significance for prognostic evaluation of the patients with non-small cell lung cancer
PubMed 3. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors.
PubMed 4. Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene
PubMed 5. FBI-1 is the first transcriptional repressor shown to act as a dual regulator in adipogenesis exerting repressor activities on target genes by both, direct and indirect mechanisms.
PubMed 6. Through the two-step purification, Zbtb7A protein was purified in high purity and its production reached up to as high as 18 mg/L. These results indicated that an effective procedure for expressing and purifying human Zbtb7A in P. pastoris was established
PubMed 7. elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy
PubMed 8. found that FBI-1 binds to inverted sequence repeats downstream of the HIV-1 transcription start site
PubMed 9. may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation
PubMed 10. POZ domain of FBI1 represses transcription of ADH5.
PubMed 11. The sumoylation target lysine residue at amino acid 61, which is located in the middle of the POZ-domain, is important because K61R mutation resulted in a much weaker molecular interaction with corepressors.
PubMed 12. FBI-1 enhances transcription of the NF-kappaB-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB
PubMed 13. Results suggest that FBI-1 is a cellular factor that preferentially associates with active chromatin and that can specifically stimulate Tat-activated HIV-1 transcription.
PubMed 14. Pokemon is aberrantly overexpressed in human cancers and that its expression levels predict biological behaviour and clinical outcome
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Tat Binding of FBI-1 to HIV-1 Tat is mediated by the zinc finger (ZF) domain of FBI-1 (amino acids 377-584) and is diminished by point mutations in Tat at amino acids 18, 30, and 31 PubMed
2. FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and Tat protein and specifically stimulates Tat activity PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_056982.1   B cell lymphoma 6 protein   BCL6      HPRD    PubMed
 
  NP_056982.1   Transcription factor Sp1   SP1      HPRD    PubMed
 
  NP_056982.1   Transcription factor Sp3   SP3      HPRD    PubMed
 
  NP_056982.1   Transcription factor Sp4   SP4      HPRD    PubMed
 
  NP_056982.1   NP_056982.1   ZBTB7A      HPRD    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:119488   BioGRID:107076   BCL6      BioGRID    PubMed
Reconstituted Complex
  BioGRID:119488   BioGRID:203414   Sp1      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:119488   BioGRID:119488   ZBTB7A      BioGRID    PubMed

[Top][Help]General gene information

Markers

A006W32(e-PCR)
Links: UniSTS:60674
RH47736(e-PCR)
Links: UniSTS:2691
MARC_21177-21178:1027091454:1(e-PCR)
Links: UniSTS:268502
STS-R06252(e-PCR)
Links: UniSTS:31198
RH79859(e-PCR)
Links: UniSTS:83687

Homology

Homologs of the ZBTB7A gene The ZBTB7A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.


Map Viewer (Mouse, Rat)

[Top][Help]General protein information

Preferred Names
zinc finger and BTB domain containing 7A
Names
zinc finger and BTB domain containing 7A
lymphoma related factor
HIV-1 inducer of short transcripts binding protein
zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_015898.2 → NP_056982.1  zinc finger and BTB domain containing 7A

    Source sequence(s)
    AF000561,AF097916,BC019108,BM696365,BQ082585,BQ711712,CB047382,CB242327
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    O95365
    UniProtKB/TrEMBL
    Q8TB76
    Conserved Domains (3) summary
    COG5048
    Location:382 – 445
    Blast Score: 97
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:410 – 432
    Blast Score: 89
    zf-C2H2; Zinc finger, C2H2 type
    cl02518
    Location:24 – 131
    Blast Score: 333
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000019.9

    Range
    4045215..4066815, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_011255.14 

    Range
    3985215..4006815, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000062.1

    Range
    3984709..4006259, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_927173.1 

    Range
    3243433..3264983, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000151.1

    Range
    3809543..3824110
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838477.2 

    Range
    2400131..2414698
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC016586.9  (70253..91853)   None
  genomic   CH471139.2   EAW69266.1
       EAW69267.1
       EAW69268.1
       EAW69269.1
       EAW69270.1
       EAW69271.1
       EAW69272.1
  mRNA   AF000561.1   AAB58414.1
  mRNA   AF097916.1   AAC72973.1
  mRNA   AL390151.1   None
  mRNA   BC019108.1   AAH19108.1
  mRNA   BC080608.1   None
  mRNA   BC084568.1   AAH84568.1
  mRNA   BC113511.1   AAI13512.1
  mRNA   BM696365.1   None
  mRNA   BQ082585.1   None
  mRNA   BQ711712.1   None
  mRNA   CB047382.1   None
  mRNA   CB242327.1   None
Protein Accession   Links
O95365.1   GenPept   UniProtKB/Swiss-Prot:O95365
Q8TB76   GenPept   UniProtKB/TrEMBL:Q8TB76

[Top][Help]Additional Links

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