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    SIX1 SIX homeobox 1 [ Bos taurus (cattle) ]

    Gene ID: 511371, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SIX1provided by VGNC
    Official Full Name
    SIX homeobox 1provided by VGNC
    Primary source
    VGNC:VGNC:54483
    See related
    BGD:BT15472; Ensembl:ENSBTAG00000012139
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (72816298..72821034, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene SIX homeobox 6 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene ferritin light chain-like Neighboring gene SNRPN upstream reading frame protein-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG. Wei DW, et al. Sci Rep, 2017 Oct 3. PMID 28974698, Free PMC Article
    2. Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2. Wei D, et al. Int J Mol Sci, 2018 Jan 16. PMID 29337851, Free PMC Article
    3. NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Wei DW, et al. Sci Rep, 2017 Aug 11. PMID 28801681, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MyoG drives SIX1 transcription indirectly via the MEF3 motif. Taken together these interactions suggest a key functional role for SIX1 in mediating skeletal muscle growth in cattle
      Title: Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG.
    2. Data show that nuclear respiratory factor 1 (NRF1) and zinc finger and SCAN domain-containing protein 10 (ZSCAN10) binding occurred in the promoter region of diplotypes H1-H2 to regulate homeobox protein SIX1 (SIX1) transcriptional activity.
      Title: NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle.
    3. histone H4 and E2F2 bind to the -216/-28 region and play important roles in SIX1 methylation regulation during development.
      Title: Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein SIX1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72816298..72821034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002691019.7 → XP_002691065.3  homeobox protein SIX1

      See identical proteins and their annotated locations for XP_002691065.3

      UniProtKB/TrEMBL
      F6Q7X7
      Related
      ENSBTAP00000016104.4, ENSBTAT00000016104.5
      Conserved Domains (2) summary
      cd00086
      Location:129 → 180
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:9 → 118
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
    Nucleotide Protein Strain
    Heading Accession and Version

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