TOMM40 translocase of outer mitochondrial membrane 40 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TOMM40provided by VGNC
Official Full Name: translocase of outer mitochondrial membrane 40provided by VGNC
Primary source: VGNC:VGNC:49148
See related: Ensembl:ENSBTAG00000001781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: Tom40A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (52618989..52630589)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.
Title: N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM40 homolog

Names: translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog; translocase of outer mitochondrial membrane 40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075438.1 → NP_001068906.1 mitochondrial import receptor subunit TOM40 homolog

See identical proteins and their annotated locations for NP_001068906.1

Status: PROVISIONAL

Source sequence(s)

BC116105

UniProtKB/Swiss-Prot

Q1LZB5

UniProtKB/TrEMBL

E2GEZ2

Related

ENSBTAP00000032188.4, ENSBTAT00000032251.6

Conserved Domains (1) summary

cd07305
Location:77 → 361

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

Range

52618989..52630589

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024978114.2 → XP_024833882.1 mitochondrial import receptor subunit TOM40 homolog isoform X1

UniProtKB/Swiss-Prot

Q1LZB5

UniProtKB/TrEMBL

E2GEZ2

Conserved Domains (1) summary

cd07305
Location:77 → 361

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)