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    RGL2 ral guanine nucleotide dissociation stimulator like 2 [ Bos taurus (cattle) ]

    Gene ID: 504334, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RGL2provided by VGNC
    Official Full Name
    ral guanine nucleotide dissociation stimulator like 2provided by VGNC
    Primary source
    VGNC:VGNC:33904
    See related
    BGD:BT23913; Ensembl:ENSBTAG00000016827
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RGL2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7465582..7472693, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene prefoldin subunit 6 Neighboring gene TAP binding protein Neighboring gene microRNA mir-2376 Neighboring gene zinc finger and BTB domain containing 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139909

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075154.1 → NP_001068622.1  ral guanine nucleotide dissociation stimulator-like 2

      See identical proteins and their annotated locations for NP_001068622.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119934
      UniProtKB/TrEMBL
      A0A3Q1MD07, Q0VCY4
      Related
      ENSBTAP00000022385.4, ENSBTAT00000022385.5
      Conserved Domains (3) summary
      cd00153
      Location:649 → 734
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:91 → 213
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:240 → 510
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7465582..7472693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983415.2 → XP_024839183.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MD07
      Conserved Domains (3) summary
      cd00153
      Location:526 → 611
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      cd00155
      Location:117 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cl02520
      Location:12 → 90
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    Nucleotide Protein Strain
    Heading Accession and Version

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