Tasl TLR adaptor interacting with endolysosomal SLC15A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taslprovided by RGD
Official Full Name: TLR adaptor interacting with endolysosomal SLC15A4provided by RGD
Primary source: RGD:1565785
See related: Ensembl:ENSRNOG00000003748 AllianceGenome:RGD:1565785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565785
Summary: Predicted to be involved in positive regulation of innate immune response; positive regulation of toll-like receptor signaling pathway; and regulation of lysosomal lumen pH. Predicted to be located in endolysosome membrane. Orthologous to human TASL (TLR adaptor interacting with endolysosomal SLC15A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 80.3), Thymus (RPKM 29.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (54354755..54373930)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (50403962..50423141)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (54390733..54409466)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal lumen pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lysosomal lumen pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLR adapter interacting with SLC15A4 on the lysosome

Names: uncharacterized protein CXorf21 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.