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    Ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500711, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ppp4r4provided by RGD
    Official Full Name
    protein phosphatase 4, regulatory subunit 4provided by RGD
    Primary source
    RGD:1560932
    See related
    Ensembl:ENSRNOG00000054052 AllianceGenome:RGD:1560932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560932
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to act upstream of or within blastocyst hatching; negative regulation of phosphoprotein phosphatase activity; and regulation of protein serine/threonine phosphatase activity. Predicted to be located in cytosol. Predicted to be part of protein serine/threonine phosphatase complex. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 62.9), Brain (RPKM 42.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128427884..128518776)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122663172..122753988)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127400585..127497280)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene uncharacterized LOC108351293 Neighboring gene serpin family A member 10 Neighboring gene serpin family A member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871, Free PMC Article
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein serine/threonine phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134632.2 → NP_001128104.2  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JV26
      Related
      ENSRNOP00000069324.2, ENSRNOT00000087429.2

    2. NM_001414974.1 → NP_001401903.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZPK8
      Related
      ENSRNOP00000080384.1, ENSRNOT00000104568.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      128427884..128518776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262336.1 → XP_063118406.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPK8

    2. XM_063262337.1 → XP_063118407.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

    3. XM_063262338.1 → XP_063118408.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

    4. XM_039112758.2 → XP_038968686.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADF5
      Conserved Domains (1) summary
      sd00044
      Location:105 → 135
      HEAT; HEAT repeat [structural motif]

    5. XM_039112759.2 → XP_038968687.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADF5
      Conserved Domains (1) summary
      sd00044
      Location:105 → 135
      HEAT; HEAT repeat [structural motif]

    6. XM_039112760.2 → XP_038968688.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

      Conserved Domains (1) summary
      sd00044
      Location:157 → 185
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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