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    me3 malic enzyme 3, NADP(+)-dependent, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 492719, updated on 11-Apr-2024

    Summary

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    Official Symbol
    me3provided by ZNC
    Official Full Name
    malic enzyme 3, NADP(+)-dependent, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-294
    See related
    Ensembl:ENSDARG00000002305 AllianceGenome:ZFIN:ZDB-GENE-041111-294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7151680; wu:fi43b04; zgc:163117
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in pectoral fin musculature and pronephric duct. Orthologous to several human genes including ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34246384..34260191, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34437199..34451006, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene mitochondrial pyruvate carrier 2b Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene immunoglobulin-like domain containing receptor 1b Neighboring gene immunoglobulin-like domain containing receptor 2 Neighboring gene uncharacterized LOC103911676

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article
    2. Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule. Sugano Y, et al. Pflugers Arch, 2017 Aug. PMID 28656378
    3. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593
    4. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Konzer A, et al. Mol Cell Proteomics, 2013 Jun. PMID 23412571, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malic enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent malic enzyme, mitochondrial
    NP_001082825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089356.1 → NP_001082825.1  NADP-dependent malic enzyme, mitochondrial

      See identical proteins and their annotated locations for NP_001082825.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139717
      UniProtKB/TrEMBL
      A0A8M1NCY2, A4QPA0
      Related
      ENSDARP00000006882.8, ENSDART00000012385.9
      Conserved Domains (3) summary
      cd05312
      Location:304 → 580
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:47 → 587
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:113 → 294
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      34246384..34260191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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