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    MMP8 matrix metallopeptidase 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 489429, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MMP8provided by VGNC
    Official Full Name
    matrix metallopeptidase 8provided by VGNC
    Primary source
    VGNC:VGNC:43289
    See related
    Ensembl:ENSCAFG00845000899
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (29087831..29098581)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (28984875..28995648)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (29177264..29188014)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (29122825..29133583)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (29002064..29012820)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene stromelysin-1-like Neighboring gene interstitial collagenase-like Neighboring gene matrix metallopeptidase 27 Neighboring gene matrix metallopeptidase 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil collagenase
    Names
    matrix metallopeptidase 8 (neutrophil collagenase)
    XP_038331140.1
    XP_038392281.1
    XP_038456487.1
    XP_038521019.1
    XP_546547.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      29087831..29098581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038665091.1 → XP_038521019.1  neutrophil collagenase

      UniProtKB/TrEMBL
      A0A8C0K9M4, A0A8I3MXC2, A0A8P0SJK1
      Related
      ENSCAFP00845001189.1, ENSCAFT00845001511.1
      Conserved Domains (3) summary
      cd00094
      Location:287 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 273
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      29122825..29133583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038475212.1 → XP_038331140.1  neutrophil collagenase

      Conserved Domains (3) summary
      cd00094
      Location:287 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 273
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      29002064..29012820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038600559.1 → XP_038456487.1  neutrophil collagenase

      Conserved Domains (3) summary
      cd00094
      Location:287 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 273
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      29177264..29188014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038536353.1 → XP_038392281.1  neutrophil collagenase

      UniProtKB/TrEMBL
      A0A8C0K9M4, A0A8I3MXC2, A0A8P0SJK1
      Conserved Domains (3) summary
      cd00094
      Location:287 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 273
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      28984875..28995648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_546547.7 → XP_546547.3  neutrophil collagenase

      UniProtKB/TrEMBL
      A0A8C0K9M4, A0A8I3MXC2, A0A8P0SJK1
      Conserved Domains (3) summary
      cd00094
      Location:287 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 273
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 97
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein
    Heading Accession and Version

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