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    PCSK4 proprotein convertase subtilisin/kexin type 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 485083, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PCSK4provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 4provided by VGNC
    Primary source
    VGNC:VGNC:44323
    See related
    Ensembl:ENSCAFG00845012009
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (58101329..58107483)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (57162069..57168223)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (57839018..57845172)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (57157552..57163690)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (57637009..57643163)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091408 Neighboring gene ADAMTS like 5 Neighboring gene receptor accessory protein 6 Neighboring gene translation initiation factor IF-2-like Neighboring gene chromosome 20 C19orf25 homolog Neighboring gene APC regulator of WNT signaling pathway 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      58101329..58107483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429297.1 → XP_038285225.1  proprotein convertase subtilisin/kexin type 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:664 → 700
      FU; Furin-like repeats
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038429298.1 → XP_038285226.1  proprotein convertase subtilisin/kexin type 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:663 → 699
      FU; Furin-like repeats
      pfam01483
      Location:504 → 590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038429302.1 → XP_038285230.1  proprotein convertase subtilisin/kexin type 4 isoform X6

      UniProtKB/TrEMBL
      A0A8C0KXJ7, A0A8C0NC64, A0A8C0QE69, A0A8I3NX00
      Related
      ENSCAFP00845017100.1, ENSCAFT00845021744.1
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:650 → 686
      FU; Furin-like repeats
      pfam01483
      Location:491 → 577
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_038429304.1 → XP_038285232.1  proprotein convertase subtilisin/kexin type 4 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:613 → 649
      FU; Furin-like repeats
      pfam01483
      Location:457 → 540
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    5. XM_038429300.1 → XP_038285228.1  proprotein convertase subtilisin/kexin type 4 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:659 → 695
      FU; Furin-like repeats
      pfam01483
      Location:500 → 586
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    6. XM_038429301.1 → XP_038285229.1  proprotein convertase subtilisin/kexin type 4 isoform X5

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:658 → 694
      FU; Furin-like repeats
      pfam01483
      Location:499 → 585
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    7. XM_038429303.1 → XP_038285231.1  proprotein convertase subtilisin/kexin type 4 isoform X7

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:645 → 681
      FU; Furin-like repeats
      pfam01483
      Location:486 → 572
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    8. XM_038429305.1 → XP_038285233.1  proprotein convertase subtilisin/kexin type 4 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:608 → 644
      FU; Furin-like repeats
      pfam01483
      Location:452 → 535
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    9. XM_038429299.1 → XP_038285227.1  proprotein convertase subtilisin/kexin type 4 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:118 → 407
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:662 → 698
      FU; Furin-like repeats
      pfam01483
      Location:503 → 589
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    10. XM_038429306.1 → XP_038285234.1  proprotein convertase subtilisin/kexin type 4 isoform X10

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    11. XM_038429307.1 → XP_038285235.1  proprotein convertase subtilisin/kexin type 4 isoform X11

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      57157552..57163690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038504827.1 → XP_038360755.1  proprotein convertase subtilisin/kexin type 4 isoform X1

    2. XM_038504836.1 → XP_038360764.1  proprotein convertase subtilisin/kexin type 4 isoform X12

    3. XM_038504828.1 → XP_038360756.1  proprotein convertase subtilisin/kexin type 4 isoform X2

    4. XM_038504832.1 → XP_038360760.1  proprotein convertase subtilisin/kexin type 4 isoform X6

    5. XM_038504834.1 → XP_038360762.1  proprotein convertase subtilisin/kexin type 4 isoform X8

    6. XM_038504830.1 → XP_038360758.1  proprotein convertase subtilisin/kexin type 4 isoform X4

    7. XM_038504831.1 → XP_038360759.1  proprotein convertase subtilisin/kexin type 4 isoform X5

    8. XM_038504833.1 → XP_038360761.1  proprotein convertase subtilisin/kexin type 4 isoform X7

    9. XM_038504835.1 → XP_038360763.1  proprotein convertase subtilisin/kexin type 4 isoform X9

    10. XM_038504829.1 → XP_038360757.1  proprotein convertase subtilisin/kexin type 4 isoform X3

    11. XM_038504837.1 → XP_038360765.1  proprotein convertase subtilisin/kexin type 4 isoform X10

    12. XM_038504838.1 → XP_038360766.1  proprotein convertase subtilisin/kexin type 4 isoform X11

      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      57637009..57643163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038632090.1 → XP_038488018.1  proprotein convertase subtilisin/kexin type 4 isoform X1

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:664 → 700
      FU; Furin-like repeats
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038632091.1 → XP_038488019.1  proprotein convertase subtilisin/kexin type 4 isoform X2

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:663 → 699
      FU; Furin-like repeats
      pfam01483
      Location:504 → 590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038632095.1 → XP_038488023.1  proprotein convertase subtilisin/kexin type 4 isoform X6

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:650 → 686
      FU; Furin-like repeats
      pfam01483
      Location:491 → 577
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_038632097.1 → XP_038488025.1  proprotein convertase subtilisin/kexin type 4 isoform X8

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:613 → 649
      FU; Furin-like repeats
      pfam01483
      Location:457 → 540
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    5. XM_038632093.1 → XP_038488021.1  proprotein convertase subtilisin/kexin type 4 isoform X4

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:659 → 695
      FU; Furin-like repeats
      pfam01483
      Location:500 → 586
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    6. XM_038632094.1 → XP_038488022.1  proprotein convertase subtilisin/kexin type 4 isoform X5

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:658 → 694
      FU; Furin-like repeats
      pfam01483
      Location:499 → 585
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    7. XM_038632096.1 → XP_038488024.1  proprotein convertase subtilisin/kexin type 4 isoform X7

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:645 → 681
      FU; Furin-like repeats
      pfam01483
      Location:486 → 572
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    8. XM_038632098.1 → XP_038488026.1  proprotein convertase subtilisin/kexin type 4 isoform X9

      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:608 → 644
      FU; Furin-like repeats
      pfam01483
      Location:452 → 535
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    9. XM_038632092.1 → XP_038488020.1  proprotein convertase subtilisin/kexin type 4 isoform X3

      Conserved Domains (4) summary
      cd04059
      Location:118 → 407
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:662 → 698
      FU; Furin-like repeats
      pfam01483
      Location:503 → 589
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    10. XM_038632099.1 → XP_038488027.1  proprotein convertase subtilisin/kexin type 4 isoform X10

      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    11. XM_038632100.1 → XP_038488028.1  proprotein convertase subtilisin/kexin type 4 isoform X11

      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      57839018..57845172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038567979.1 → XP_038423907.1  proprotein convertase subtilisin/kexin type 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:664 → 700
      FU; Furin-like repeats
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038567980.1 → XP_038423908.1  proprotein convertase subtilisin/kexin type 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:663 → 699
      FU; Furin-like repeats
      pfam01483
      Location:504 → 590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038567984.1 → XP_038423912.1  proprotein convertase subtilisin/kexin type 4 isoform X6

      UniProtKB/TrEMBL
      A0A8C0KXJ7, A0A8C0NC64, A0A8C0QE69, A0A8I3NX00
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:650 → 686
      FU; Furin-like repeats
      pfam01483
      Location:491 → 577
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_038567986.1 → XP_038423914.1  proprotein convertase subtilisin/kexin type 4 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:613 → 649
      FU; Furin-like repeats
      pfam01483
      Location:457 → 540
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    5. XM_038567982.1 → XP_038423910.1  proprotein convertase subtilisin/kexin type 4 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:659 → 695
      FU; Furin-like repeats
      pfam01483
      Location:500 → 586
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    6. XM_038567983.1 → XP_038423911.1  proprotein convertase subtilisin/kexin type 4 isoform X5

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:658 → 694
      FU; Furin-like repeats
      pfam01483
      Location:499 → 585
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    7. XM_038567985.1 → XP_038423913.1  proprotein convertase subtilisin/kexin type 4 isoform X7

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:645 → 681
      FU; Furin-like repeats
      pfam01483
      Location:486 → 572
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    8. XM_038567987.1 → XP_038423915.1  proprotein convertase subtilisin/kexin type 4 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:608 → 644
      FU; Furin-like repeats
      pfam01483
      Location:452 → 535
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    9. XM_038567981.1 → XP_038423909.1  proprotein convertase subtilisin/kexin type 4 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:118 → 407
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:662 → 698
      FU; Furin-like repeats
      pfam01483
      Location:503 → 589
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    10. XM_038567989.1 → XP_038423917.1  proprotein convertase subtilisin/kexin type 4 isoform X10

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    11. XM_038567990.1 → XP_038423918.1  proprotein convertase subtilisin/kexin type 4 isoform X11

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      57162069..57168223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022407280.2 → XP_022262988.2  proprotein convertase subtilisin/kexin type 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:664 → 700
      FU; Furin-like repeats
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_022407281.2 → XP_022262989.2  proprotein convertase subtilisin/kexin type 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:663 → 699
      FU; Furin-like repeats
      pfam01483
      Location:504 → 590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_542201.7 → XP_542201.4  proprotein convertase subtilisin/kexin type 4 isoform X6

      UniProtKB/TrEMBL
      A0A8C0KXJ7, A0A8C0NC64, A0A8C0QE69, A0A8I3NX00
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:650 → 686
      FU; Furin-like repeats
      pfam01483
      Location:491 → 577
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_022407288.2 → XP_022262996.2  proprotein convertase subtilisin/kexin type 4 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:613 → 649
      FU; Furin-like repeats
      pfam01483
      Location:457 → 540
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    5. XM_022407283.2 → XP_022262991.2  proprotein convertase subtilisin/kexin type 4 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:659 → 695
      FU; Furin-like repeats
      pfam01483
      Location:500 → 586
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    6. XM_022407284.2 → XP_022262992.2  proprotein convertase subtilisin/kexin type 4 isoform X5

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:658 → 694
      FU; Furin-like repeats
      pfam01483
      Location:499 → 585
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    7. XM_022407287.2 → XP_022262995.2  proprotein convertase subtilisin/kexin type 4 isoform X7

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:645 → 681
      FU; Furin-like repeats
      pfam01483
      Location:486 → 572
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    8. XM_022407289.2 → XP_022262997.2  proprotein convertase subtilisin/kexin type 4 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:608 → 644
      FU; Furin-like repeats
      pfam01483
      Location:452 → 535
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    9. XM_022407282.2 → XP_022262990.2  proprotein convertase subtilisin/kexin type 4 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QE69
      Conserved Domains (4) summary
      cd04059
      Location:118 → 407
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:662 → 698
      FU; Furin-like repeats
      pfam01483
      Location:503 → 589
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    10. XM_022407291.2 → XP_022262999.2  proprotein convertase subtilisin/kexin type 4 isoform X10

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    11. XM_022407292.2 → XP_022263000.2  proprotein convertase subtilisin/kexin type 4 isoform X11

      UniProtKB/TrEMBL
      A0A8C0RYZ2
      Conserved Domains (3) summary
      cd04059
      Location:120 → 409
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:505 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:39 → 109
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version

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