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    IGF2 insulin like growth factor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 483664, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IGF2provided by VGNC
    Official Full Name
    insulin like growth factor 2provided by VGNC
    Primary source
    VGNC:VGNC:41897
    See related
    Ensembl:ENSCAFG00845011017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (46973499..46991455, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (44906773..44921790, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (46751952..46766988, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (46425198..46440216, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (46005530..46020544, complement)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene H19, imprinted maternally expressed transcript (non-protein coding) Neighboring gene uncharacterized LOC111090823 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene microRNA mir-483 Neighboring gene insulin Neighboring gene tyrosine hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra. Gültiken N, et al. Acta Vet Hung, 2021 Apr 22. PMID 33891559
    2. Serum concentration and skin tissue expression of insulin-like growth factor 2 in canine generalized demodicosis. Yarim GF, et al. Vet Dermatol, 2015 Dec. PMID 26489526
    3. Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity. Finotello R, et al. Vet Comp Oncol, 2016 Jun. PMID 24428588
    4. Imprinting of canine IGF2 and H19. Brabazon DC, et al. Anim Genet, 2022 Feb. PMID 34676575
    5. Estrous detection with an activity and rumination monitoring system in an organic grazing and a low-input conventional dairy herd. Pereira GM, et al. Anim Reprod Sci, 2020 Oct. PMID 32861115

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imprinting of canine IGF2 and H19.
      Title: Imprinting of canine IGF2 and H19.
    2. Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra.
      Title: Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra.
    3. Estrous detection with an activity and rumination monitoring system in an organic grazing and a low-input conventional dairy herd.
      Title: Estrous detection with an activity and rumination monitoring system in an organic grazing and a low-input conventional dairy herd.
    4. IGF-II-omas can be differentiated from insulinomas through hypoinsulinaemia, IGF-II positive and insulin negative immunostaining.
      Title: Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity.
    5. Serum concentration and skin tissue expression of IGF-2 were increased in dogs with generalized demodicosis compared with control dogs.
      Title: Serum concentration and skin tissue expression of insulin-like growth factor 2 in canine generalized demodicosis.
    6. Hypoglycemia attributed to an insulin-like growth factor type-II secreting hepatocellular carcinoma is reported in a single female dog.
      Title: Paraneoplastic hypoglycemia due to an insulin-like growth factor type-II secreting hepatocellular carcinoma in a dog.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor II
    Names
    insulin-like growth factor 2 (somatomedin A)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195403.2 → NP_001182332.2  insulin-like growth factor II isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0KY17, E0W6Z3
      Conserved Domains (2) summary
      cd04368
      Location:30 → 94
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:115 → 169
      IGF2_C; Insulin-like growth factor II E-peptide

    2. NM_001195825.2 → NP_001182754.2  insulin-like growth factor II isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a), which is also encoded by variant 3.
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0Z6J8, E0W6Z5, J9NYS6
      Related
      ENSCAFP00845015339.1, ENSCAFT00845019611.1
      Conserved Domains (2) summary
      cd04368
      Location:30 → 97
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:118 → 172
      IGF2_C; Insulin-like growth factor II E-peptide

    3. NM_001195826.2 → NP_001182755.2  insulin-like growth factor II isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 both encode isoform a.
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0Z6J8, E0W6Z5, J9NYS6
      Conserved Domains (2) summary
      cd04368
      Location:30 → 97
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:118 → 172
      IGF2_C; Insulin-like growth factor II E-peptide

    4. NM_001195827.2 → NP_001182756.2  insulin-like growth factor II isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. Variants 2 and 4 both encode isoform b, which is shorter than isoform a.
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0KY17, E0W6Z3
      Conserved Domains (2) summary
      cd04368
      Location:30 → 94
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:115 → 169
      IGF2_C; Insulin-like growth factor II E-peptide

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      46973499..46991455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038423442.1 → XP_038279370.1  insulin-like growth factor II isoform X1

      UniProtKB/TrEMBL
      A0A8C0Z6J8, E0W6Z5, J9NYS6
      Conserved Domains (2) summary
      cd04368
      Location:30 → 97
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:118 → 172
      IGF2_C; Insulin-like growth factor II E-peptide

    2. XM_038423441.1 → XP_038279369.1  insulin-like growth factor II isoform X1

      UniProtKB/TrEMBL
      A0A8C0Z6J8, E0W6Z5, J9NYS6
      Conserved Domains (2) summary
      cd04368
      Location:30 → 97
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:118 → 172
      IGF2_C; Insulin-like growth factor II E-peptide

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      46425198..46440216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      46005530..46020544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      46751952..46766988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      44906773..44921790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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