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    DENND2A DENN domain containing 2A [ Canis lupus familiaris (dog) ]

    Gene ID: 482766, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DENND2Aprovided by VGNC
    Official Full Name
    DENN domain containing 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:39886
    See related
    Ensembl:ENSCAFG00845031062
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DENND2A in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (8296862..8400910)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (9220090..9324042)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (8160683..8264684)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (8247726..8351868)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (8092452..8196323)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090233 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2 Neighboring gene 40S ribosomal protein S27-like Neighboring gene U6 spliceosomal RNA Neighboring gene makorin ring finger protein 1 Neighboring gene RAB19, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DENN domain-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      8296862..8400910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689098.1 → XP_038545026.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3S7Y4
      Related
      ENSCAFP00845043430.1, ENSCAFT00845055219.1
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_038689097.1 → XP_038545025.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3S7Y4
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_038689094.1 → XP_038545022.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3SCX4
      Related
      ENSCAFP00845043429.1, ENSCAFT00845055218.1
      Conserved Domains (3) summary
      smart00801
      Location:1014 → 1080
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:779 → 962
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_038689096.1 → XP_038545024.1  DENN domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A8I3QCM0
      Related
      ENSCAFP00845043433.1, ENSCAFT00845055222.1
      Conserved Domains (3) summary
      smart00801
      Location:1000 → 1066
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 942
      DENN; DENN (AEX-3) domain

    5. XM_038689095.1 → XP_038545023.1  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I3QCM0
      Conserved Domains (3) summary
      smart00801
      Location:1013 → 1079
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:778 → 961
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:678 → 770
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      8247726..8351868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497060.1 → XP_038352988.1  DENN domain-containing protein 2A isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_038497059.1 → XP_038352987.1  DENN domain-containing protein 2A isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_038497056.1 → XP_038352984.1  DENN domain-containing protein 2A isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1014 → 1080
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:779 → 962
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_038497058.1 → XP_038352986.1  DENN domain-containing protein 2A isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:1000 → 1066
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 942
      DENN; DENN (AEX-3) domain

    5. XM_038497057.1 → XP_038352985.1  DENN domain-containing protein 2A isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:1013 → 1079
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:778 → 961
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:678 → 770
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      8092452..8196323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623379.1 → XP_038479307.1  DENN domain-containing protein 2A isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_038623378.1 → XP_038479306.1  DENN domain-containing protein 2A isoform X4

      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_038623375.1 → XP_038479303.1  DENN domain-containing protein 2A isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1014 → 1080
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:779 → 962
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_038623377.1 → XP_038479305.1  DENN domain-containing protein 2A isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:1000 → 1066
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 942
      DENN; DENN (AEX-3) domain

    5. XM_038623376.1 → XP_038479304.1  DENN domain-containing protein 2A isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:1013 → 1079
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:778 → 961
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:678 → 770
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      8160683..8264684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559399.1 → XP_038415327.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3S7Y4
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_038559398.1 → XP_038415326.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3S7Y4
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_038559395.1 → XP_038415323.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I3QCM0, A0A8I3SCX4
      Conserved Domains (3) summary
      smart00801
      Location:1014 → 1080
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:779 → 962
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_038559397.1 → XP_038415325.1  DENN domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A8I3QCM0
      Conserved Domains (3) summary
      smart00801
      Location:1000 → 1066
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 942
      DENN; DENN (AEX-3) domain

    5. XM_038559396.1 → XP_038415324.1  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I3QCM0
      Conserved Domains (3) summary
      smart00801
      Location:1013 → 1079
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:778 → 961
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:678 → 770
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9220090..9324042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038452288.1 → XP_038308216.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8P0NQK4
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_014119895.3 → XP_013975370.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8P0NQK4
      Conserved Domains (3) summary
      smart00801
      Location:978 → 1044
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:743 → 926
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:643 → 735
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_005629553.4 → XP_005629610.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8P0NQK4, A0A8P0P171
      Conserved Domains (3) summary
      smart00801
      Location:1014 → 1080
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:779 → 962
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. XM_038452287.1 → XP_038308215.1  DENN domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A8P0NQK4
      Conserved Domains (3) summary
      smart00801
      Location:1000 → 1066
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:679 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 942
      DENN; DENN (AEX-3) domain

    5. XM_014119894.3 → XP_013975369.1  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8P0NQK4
      Conserved Domains (3) summary
      smart00801
      Location:1013 → 1079
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:778 → 961
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:678 → 770
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein
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