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    CTSO cathepsin O [ Canis lupus familiaris (dog) ]

    Gene ID: 482665, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CTSOprovided by VGNC
    Official Full Name
    cathepsin Oprovided by VGNC
    Primary source
    VGNC:VGNC:54198
    See related
    Ensembl:ENSCAFG00845010853
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (54134250..54157750, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (53762705..53786762, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (53811032..53834587, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (53387542..53411063, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (53496778..53520309, complement)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene tryptophan 2,3-dioxygenase Neighboring gene uncharacterized LOC111090110 Neighboring gene casein kinase I-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin O
    XP_005629509.2
    XP_038352625.1
    XP_038415111.1
    XP_038478958.1
    XP_038544630.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      54134250..54157750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038688702.1 → XP_038544630.1  cathepsin O isoform X1

      UniProtKB/TrEMBL
      A0A8C0SLA3, A0A8I3NHB2
      Related
      ENSCAFP00845014970.1, ENSCAFT00845019160.1
      Conserved Domains (2) summary
      cd02248
      Location:108 → 318
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      cl22448
      Location:41 → 79
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      53387542..53411063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038496697.1 → XP_038352625.1  cathepsin O isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      53496778..53520309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623030.1 → XP_038478958.1  cathepsin O isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      53811032..53834587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559183.1 → XP_038415111.1  cathepsin O isoform X2

      UniProtKB/TrEMBL
      A0A8C0JNS2

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      53762705..53786762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005629452.2 → XP_005629509.2  cathepsin O isoform X1

      UniProtKB/TrEMBL
      A0A8C0SLA3, A0A8P0SDM5
      Conserved Domains (2) summary
      cd02248
      Location:108 → 318
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      cl22448
      Location:41 → 79
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version

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