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    NOTCH1 notch receptor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 480676, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NOTCH1provided by VGNC
    Official Full Name
    notch receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:43898
    See related
    Ensembl:ENSCAFG00845005453
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    N1ICD
    Orthologs
    human mouse all
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    Genomic context

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    See NOTCH1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (49852205..49895734)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (48226361..48269900)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (48974423..49017941)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (48633237..48676758)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (48926759..48970231)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene microRNA mir-126 Neighboring gene EGF like domain multiple 7 Neighboring gene formin-like protein 7 Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene inositol polyphosphate-5-phosphatase E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 1
    Names
    Notch homolog 1, translocation-associated
    notch 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      49852205..49895734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038677974.1 → XP_038533902.1  neurogenic locus notch homolog protein 1

      UniProtKB/TrEMBL
      A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
      Related
      ENSCAFP00845007633.1, ENSCAFT00845009762.1
      Conserved Domains (10) summary
      smart00004
      Location:1443 → 1480
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1930 → 2120
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:870 → 906
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1879 → 1924
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1533 → 1562
      Notch; LNR domain
      pfam06816
      Location:1568 → 1622
      NOD; NOTCH protein
      pfam07684
      Location:1672 → 1731
      NODP; NOTCH protein
      pfam11936
      Location:2497 → 2559
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1931 → 2024
      Ank_2; Ankyrin repeats (3 copies)
      cd21702
      Location:1719 → 1798
      JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      48633237..48676758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038486885.1 → XP_038342813.1  neurogenic locus notch homolog protein 1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      48926759..48970231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038612681.1 → XP_038468609.1  neurogenic locus notch homolog protein 1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      48974423..49017941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038548751.1 → XP_038404679.1  neurogenic locus notch homolog protein 1

      UniProtKB/TrEMBL
      A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
      Conserved Domains (10) summary
      smart00004
      Location:1443 → 1480
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1930 → 2120
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:870 → 906
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1879 → 1924
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1533 → 1562
      Notch; LNR domain
      pfam06816
      Location:1568 → 1622
      NOD; NOTCH protein
      pfam07684
      Location:1672 → 1731
      NODP; NOTCH protein
      pfam11936
      Location:2497 → 2559
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1931 → 2024
      Ank_2; Ankyrin repeats (3 copies)
      cd21702
      Location:1719 → 1798
      JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      48226361..48269900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038614892.1 → XP_038470820.1  neurogenic locus notch homolog protein 1

      UniProtKB/TrEMBL
      A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
      Conserved Domains (10) summary
      smart00004
      Location:1443 → 1480
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1930 → 2120
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:870 → 906
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1879 → 1924
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1533 → 1562
      Notch; LNR domain
      pfam06816
      Location:1568 → 1622
      NOD; NOTCH protein
      pfam07684
      Location:1672 → 1731
      NODP; NOTCH protein
      pfam11936
      Location:2497 → 2559
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1931 → 2024
      Ank_2; Ankyrin repeats (3 copies)
      cd21702
      Location:1719 → 1798
      JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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