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    PIAS1 protein inhibitor of activated STAT 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478350, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PIAS1provided by VGNC
    Official Full Name
    protein inhibitor of activated STAT 1provided by VGNC
    Primary source
    VGNC:VGNC:44519
    See related
    Ensembl:ENSCAFG00845018319
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 30
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (32312019..32428219)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (32050874..32167015)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (32548145..32664285)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (32240403..32356487)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (32302308..32418433)

    Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866839 Neighboring gene uncharacterized LOC119866926 Neighboring gene uncharacterized LOC111093358 Neighboring gene calmodulin like 4 Neighboring gene CLN6 transmembrane ER protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SUMO ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS1
    XP_005638593.1
    XP_022268558.2
    XP_022268560.1
    XP_022268561.1
    XP_038298685.1
    XP_038298686.1
    XP_038298687.1
    XP_038298688.1
    XP_038298689.1
    XP_038298690.1
    XP_038317573.1
    XP_038373123.1
    XP_038373124.1
    XP_038373125.1
    XP_038373126.1
    XP_038373127.1
    XP_038373128.1
    XP_038436730.1
    XP_038436731.1
    XP_038436732.1
    XP_038436733.1
    XP_038436734.1
    XP_038436735.1
    XP_038501068.1
    XP_038501070.1
    XP_038501071.1
    XP_038501072.1
    XP_038501073.1
    XP_038501074.1
    XP_535524.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051834.1 Reference ROS_Cfam_1.0

      Range
      32312019..32428219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038442757.1 → XP_038298685.1  E3 SUMO-protein ligase PIAS1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    2. XM_038442762.1 → XP_038298690.1  E3 SUMO-protein ligase PIAS1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    3. XM_038442760.1 → XP_038298688.1  E3 SUMO-protein ligase PIAS1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0K449, A0A8C0N9Y3, A0A8I3P120
      Related
      ENSCAFP00845025662.1, ENSCAFT00845032791.1
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:332 → 379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137 → 285
      PINIT; PINIT domain

    4. XM_038442759.1 → XP_038298687.1  E3 SUMO-protein ligase PIAS1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    5. XM_038442761.1 → XP_038298689.1  E3 SUMO-protein ligase PIAS1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120, A0A8I3S3B9, A0A8P0PGR2
      Related
      ENSCAFP00845025573.1, ENSCAFT00845032691.1
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:323 → 370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128 → 276
      PINIT; PINIT domain

    6. XM_038442758.1 → XP_038298686.1  E3 SUMO-protein ligase PIAS1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8C0TUF7, A0A8I3NX02, A0A8I3P120
      Related
      ENSCAFP00845025810.1, ENSCAFT00845032984.1
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049290.1 Alternate UMICH_Zoey_3.1

      Range
      32240403..32356487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038517195.1 → XP_038373123.1  E3 SUMO-protein ligase PIAS1 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    2. XM_038517200.1 → XP_038373128.1  E3 SUMO-protein ligase PIAS1 isoform X6

      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    3. XM_038517198.1 → XP_038373126.1  E3 SUMO-protein ligase PIAS1 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:332 → 379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137 → 285
      PINIT; PINIT domain

    4. XM_038517197.1 → XP_038373125.1  E3 SUMO-protein ligase PIAS1 isoform X3

      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    5. XM_038517199.1 → XP_038373127.1  E3 SUMO-protein ligase PIAS1 isoform X5

      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:323 → 370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128 → 276
      PINIT; PINIT domain

    6. XM_038517196.1 → XP_038373124.1  E3 SUMO-protein ligase PIAS1 isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

      Range
      32302308..32418433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038645140.1 → XP_038501068.1  E3 SUMO-protein ligase PIAS1 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    2. XM_038645146.1 → XP_038501074.1  E3 SUMO-protein ligase PIAS1 isoform X6

      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    3. XM_038645144.1 → XP_038501072.1  E3 SUMO-protein ligase PIAS1 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:332 → 379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137 → 285
      PINIT; PINIT domain

    4. XM_038645143.1 → XP_038501071.1  E3 SUMO-protein ligase PIAS1 isoform X3

      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    5. XM_038645145.1 → XP_038501073.1  E3 SUMO-protein ligase PIAS1 isoform X5

      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:323 → 370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128 → 276
      PINIT; PINIT domain

    6. XM_038645142.1 → XP_038501070.1  E3 SUMO-protein ligase PIAS1 isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

      Range
      32548145..32664285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038580802.1 → XP_038436730.1  E3 SUMO-protein ligase PIAS1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    2. XM_038580807.1 → XP_038436735.1  E3 SUMO-protein ligase PIAS1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    3. XM_038580805.1 → XP_038436733.1  E3 SUMO-protein ligase PIAS1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0K449, A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:332 → 379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137 → 285
      PINIT; PINIT domain

    4. XM_038580804.1 → XP_038436732.1  E3 SUMO-protein ligase PIAS1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    5. XM_038580806.1 → XP_038436734.1  E3 SUMO-protein ligase PIAS1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120, A0A8I3S3B9, A0A8P0PGR2
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:323 → 370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128 → 276
      PINIT; PINIT domain

    6. XM_038580803.1 → XP_038436731.1  E3 SUMO-protein ligase PIAS1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8C0TUF7, A0A8I3NX02, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      32050874..32167015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022412852.2 → XP_022268560.1  E3 SUMO-protein ligase PIAS1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    2. XM_038461645.1 → XP_038317573.1  E3 SUMO-protein ligase PIAS1 isoform X6

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:22 → 56
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:148 → 296
      PINIT; PINIT domain

    3. XM_535524.7 → XP_535524.2  E3 SUMO-protein ligase PIAS1 isoform X4

      See identical proteins and their annotated locations for XP_535524.2

      UniProtKB/TrEMBL
      A0A8C0K449, A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:332 → 379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137 → 285
      PINIT; PINIT domain

    4. XM_022412850.2 → XP_022268558.2  E3 SUMO-protein ligase PIAS1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain

    5. XM_022412853.2 → XP_022268561.1  E3 SUMO-protein ligase PIAS1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8I3P120, A0A8I3S3B9, A0A8P0PGR2
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:323 → 370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128 → 276
      PINIT; PINIT domain

    6. XM_005638536.4 → XP_005638593.1  E3 SUMO-protein ligase PIAS1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N9Y3, A0A8C0TUF7, A0A8I3NX02, A0A8I3P120
      Conserved Domains (3) summary
      smart00513
      Location:15 → 49
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336 → 383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:141 → 289
      PINIT; PINIT domain
    Nucleotide Protein
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