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    TNKS tankyrase [ Pan troglodytes (chimpanzee) ]

    Gene ID: 463982, updated on 29-Mar-2024

    Summary

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    Official Symbol
    TNKSprovided by VGNC
    Official Full Name
    tankyraseprovided by VGNC
    Primary source
    VGNC:VGNC:10224
    Locus tag
    CK820_G0040302
    See related
    Ensembl:ENSPTRG00000019972
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (15533794..15757339)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (18676385..18900598)

    Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104004250 Neighboring gene uncharacterized LOC107976233 Neighboring gene uncharacterized LOC134810813 Neighboring gene microRNA mir-597 Neighboring gene uncharacterized LOC112204172 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC129135638 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to ciliary inversin compartment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary inversin compartment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tankyrase-1; poly [ADP-ribose] polymerase tankyrase-1
    Names
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
    XP_001137443.2
    XP_016814556.1
    XP_016814557.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      15533794..15757339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016959067.4 → XP_016814556.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X2

      UniProtKB/TrEMBL
      H2QVQ9
      Related
      ENSPTRP00000069616.1

    2. XM_001137443.8 → XP_001137443.2  poly [ADP-ribose] polymerase tankyrase-1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8Q974, A0A6D2Y730, H2QVQ9, K7B8U9
      Related
      ENSPTRP00000075311.1
      Conserved Domains (7) summary
      cd09524
      Location:1024 → 1089
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      cd00204
      Location:676 → 801
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:1091 → 1313
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:371 → 399
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:339 → 389
      Ank_4; Ankyrin repeats (many copies)
      cl26072
      Location:576 → 640
      Ank_5; Ankyrin repeats (many copies)
      cl26073
      Location:417 → 810
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_016959068.4 → XP_016814557.1  poly [ADP-ribose] polymerase tankyrase-1 isoform X3

      UniProtKB/TrEMBL
      H2QVQ9
    Nucleotide Protein
    Heading Accession and Version

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