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    DEFA5 defensin alpha 5 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 463972, updated on 29-Mar-2024

    Summary

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    Official Symbol
    DEFA5provided by VGNC
    Official Full Name
    defensin alpha 5provided by VGNC
    Primary source
    VGNC:VGNC:3022
    Locus tag
    CK820_G0046871
    See related
    Ensembl:ENSPTRG00000049316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
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    Genomic context

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    See DEFA5 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (14054140..14055397, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (17201189..17202445, complement)

    Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene defensin, alpha 1 Neighboring gene defensin, alpha 7 Neighboring gene spidroin-2-like Neighboring gene small ribosomal subunit protein eS1-like Neighboring gene microRNA mir-548i-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes. Patil A, et al. Physiol Genomics, 2004 Dec 15. PMID 15494476

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in disruption of plasma membrane integrity in another organism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defensin alpha 5
    Names
    HD5(20-94)
    alpha-defensin 5, Paneth cell-specific
    defensin, alpha 1
    defensin, alpha 5, Paneth cell-specific
    defensin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012639.1 → NP_001012657.1  defensin alpha 5 precursor

      See identical proteins and their annotated locations for NP_001012657.1

      Status: PROVISIONAL

      Source sequence(s)
      AY746439
      UniProtKB/Swiss-Prot
      Q5G861
      UniProtKB/TrEMBL
      A0A2J8JJY3
      Related
      ENSPTRP00000072107.1, ENSPTRT00000103608.1
      Conserved Domains (2) summary
      pfam00323
      Location:65 → 93
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1 → 50
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      14054140..14055397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5G861.1 GenPept UniProtKB/Swiss-Prot:Q5G861

    Gene LinkOut

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