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    NGEF neuronal guanine nucleotide exchange factor [ Pan troglodytes (chimpanzee) ]

    Gene ID: 460020, updated on 29-Mar-2024

    Summary

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    Official Symbol
    NGEFprovided by VGNC
    Official Full Name
    neuronal guanine nucleotide exchange factorprovided by VGNC
    Primary source
    VGNC:VGNC:2709
    Locus tag
    CK820_G0010813
    See related
    Ensembl:ENSPTRG00000013048
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See NGEF in Genome Data Viewer
    Location:
    chromosome: 2B
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (135086789..135217185, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (134997949..135128345, complement)

    Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene potassium inwardly rectifying channel subfamily J member 13 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuraminidase 2 Neighboring gene inositol polyphosphate-5-phosphatase D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephexin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      135086789..135217185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016950725.3 → XP_016806214.1  ephexin-1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8NET0, A0A6D2X7F8, H2QJM4
      Related
      ENSPTRP00000022308.4
      Conserved Domains (3) summary
      cd11939
      Location:616 → 670
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:477 → 603
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:277 → 455
      RhoGEF; RhoGEF domain

    2. XM_516157.7 → XP_516157.3  ephexin-1 isoform X2

      See identical proteins and their annotated locations for XP_516157.3

      UniProtKB/TrEMBL
      A0A2J8NET3, A0A6D2XZN1, K7DLG7
      Related
      ENSPTRP00000068964.1
      Conserved Domains (3) summary
      cd11939
      Location:524 → 578
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:385 → 511
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:185 → 363
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

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