PRKRA protein activator of interferon induced protein kinase EIF2AK2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PRKRAprovided by VGNC
Official Full Name: protein activator of interferon induced protein kinase EIF2AK2provided by VGNC
Primary source: VGNC:VGNC:6371
Locus tag: CK820_G0001621
See related: Ensembl:ENSPTRG00000012688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2B

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	13	NC_072411.2 (80462035..80481356, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2B	NC_072400.1 (80461998..80481247, complement)

Chromosome 13 - NC_072411.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH65973 (e-PCR)
- UniSTS:53510

RH103045 (e-PCR)
- UniSTS:97379

G20228 (e-PCR)
- UniSTS:60790

A005A41 (e-PCR)
- UniSTS:60791

RH16629 (e-PCR)
- UniSTS:61059

D2S1579E (e-PCR)
- UniSTS:150663

SGC32052 (e-PCR)
- UniSTS:3812

RH47285 (e-PCR)
- UniSTS:86244

G20590 (e-PCR)
- UniSTS:56815

A005Y08 (e-PCR)
- UniSTS:56816

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables siRNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of regulatory ncRNA processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in siRNA processing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of RISC-loading complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interferon-inducible double-stranded RNA-dependent protein kinase activator A

Names: interferon-inducible double stranded RNA-dependent protein kinase activator A; protein kinase, interferon-inducible double stranded RNA dependent activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001279769.1 → NP_001266698.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A

See identical proteins and their annotated locations for NP_001266698.1

Status: PROVISIONAL

Source sequence(s)

AK306717

UniProtKB/TrEMBL

A0A2I3SAI2, G2HJ03

Conserved Domains (2) summary

smart00358
Location:10 → 75

DSRM; Double-stranded RNA binding motif

cd00048
Location:101 → 167

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

80462035..80481356 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009443668.5 → XP_009441943.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X1

See identical proteins and their annotated locations for XP_009441943.1

UniProtKB/TrEMBL

A0A2I3SAI2, A0A2J8PRE1, A0A6D2WC05, H2QJ21

Related

ENSPTRP00000021685.5

Conserved Domains (3) summary

cd19889
Location:32 → 102

DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

cd19891
Location:126 → 192

DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

cd19892
Location:239 → 310

DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
XM_063790241.1 → XP_063646311.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2
XM_016949333.4 → XP_016804822.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2

Conserved Domains (2) summary

cd19891
Location:41 → 107

DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

cd19892
Location:154 → 225

DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins