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    bic bicaudal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45827, updated on 4-Apr-2024

    Summary

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    Official Symbol
    bicprovided by FlyBase
    Official Full Name
    bicaudalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000181
    Locus tag
    Dmel_CG3644
    See related
    AllianceGenome:FB:FBgn0000181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    107/12; 5A; BcDNA.GM05329; BcDNA:GM05329; Bic; Btf; BTF3; CG3644; Dmel\CG3644; E(2)Bic; E(Bic); l(2)49Da; l(2)k10712; l(2)vr22; NAC-beta; vr22
    Summary
    Involved in several processes, including anterior/posterior axis specification; embryonic development via the syncytial blastoderm; and regulation of pole plasm oskar mRNA localization. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol and polysomal ribosome. Is expressed in several structures, including adult heart; embryonic/larval midgut; embryonic/larval muscle system; mesoderm; and ovary. Orthologous to several human genes including BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    49D6-49D6; 2-67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12870249..12871794)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8757754..8759299)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45468 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45140 Neighboring gene antisense RNA:CR43469 Neighboring gene antisense RNA:CR43468 Neighboring gene Beta-alanine transporter Neighboring gene Lifeguard

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of pattern-formation in the embryo ofDrosophila melanogaster : Characterization of the maternal-effect mutantBicaudal. Nüsslein-Volhard C. Wilehm Roux Arch Dev Biol, 1977 Sep. PMID 28305090
    2. Manipulating the anteroposterior pattern of the Drosophila embryo. Frohnhöfer HG, et al. J Embryol Exp Morphol, 1986 Oct. PMID 3625112
    3. Dominant maternal-effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos. Mohler J, et al. Genetics, 1986 Apr. PMID 3082713, Free PMC Article
    4. An exercise in rational taxonomy. Ho MW. J Theor Biol, 1990 Nov 7. PMID 2277504
    5. Mathematics and biology: a Kantian view on the history of pattern formation theory. Roth S. Dev Genes Evol, 2011 Dec. PMID 22086125, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization involved in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bicaudal
    Names
    CG3644-PA
    CG3644-PB
    bic-PA
    bic-PB
    enhancer of bicaudal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12870249..12871794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057505.5 → NP_476853.1  bicaudal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KM15, Q9U9Q7
      Related
      FBpp0086895
      Conserved Domains (1) summary
      pfam01849
      Location:38 → 90
      NAC; NAC domain

    2. NM_165954.3 → NP_725235.1  bicaudal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KM15, Q9U9Q7
      Related
      FBpp0086896
      Conserved Domains (1) summary
      pfam01849
      Location:38 → 90
      NAC; NAC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KM15 Q7KM15
    Q9U9Q7 Q9U9Q7

    Gene LinkOut

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