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    PTPRU protein tyrosine phosphatase receptor type U [ Pan troglodytes (chimpanzee) ]

    Gene ID: 456692, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PTPRUprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Uprovided by VGNC
    Primary source
    VGNC:VGNC:9890
    Locus tag
    CK820_G0048704
    See related
    Ensembl:ENSPTRG00000000447
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See PTPRU in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (201658116..201748287, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (29551006..29641178)

    Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129143191 Neighboring gene uncharacterized LOC134807796 Neighboring gene uncharacterized LOC107975865 Neighboring gene uncharacterized LOC107975866 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase U
    XP_016813217.1
    XP_016813221.1
    XP_016813223.1
    XP_016813225.1
    XP_016813230.1
    XP_016813238.1
    XP_016813245.1
    XP_016813251.1
    XP_016813255.1
    XP_016813258.1
    XP_016813261.1
    XP_024213222.1
    XP_054520966.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      201658116..201748287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016957756.3 → XP_016813245.1  receptor-type tyrosine-protein phosphatase U isoform X7

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCJ0, A0A2J8JCK4, A0A6D2YC00, A0A803KHV9, K7DAJ5
      Conserved Domains (4) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:913 → 1130
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain

    2. XM_016957749.3 → XP_016813238.1  receptor-type tyrosine-protein phosphatase U isoform X6

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A2J8JCL0, A0A6D2VVU3, A0A6D2YC00, H2R469, K7DTJ4
      Related
      ENSPTRP00000046670.6
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1195 → 1428
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1133
      Y_phosphatase; Protein-tyrosine phosphatase

    3. XM_016957734.3 → XP_016813223.1  receptor-type tyrosine-protein phosphatase U isoform X3

      UniProtKB/TrEMBL
      A0A2I3S535, A0A2I3SEZ5, A0A2I3TPD8, A0A2J8JCK1, A0A2J8JCK4, A0A6D2VXE6, A0A6D2YC00
      Related
      ENSPTRP00000090811.1
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1205 → 1438
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1143
      Y_phosphatase; Protein-tyrosine phosphatase

    4. XM_016957769.4 → XP_016813258.1  receptor-type tyrosine-protein phosphatase U isoform X9

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    5. XM_016957766.4 → XP_016813255.1  receptor-type tyrosine-protein phosphatase U isoform X8

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    6. XM_016957741.4 → XP_016813230.1  receptor-type tyrosine-protein phosphatase U isoform X5

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00
      Related
      ENSPTRP00000075554.1

    7. XM_016957736.4 → XP_016813225.1  receptor-type tyrosine-protein phosphatase U isoform X4

      UniProtKB/TrEMBL
      A0A2I3S535, A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    8. XM_016957732.4 → XP_016813221.1  receptor-type tyrosine-protein phosphatase U isoform X2

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    9. XM_016957728.4 → XP_016813217.1  receptor-type tyrosine-protein phosphatase U isoform X1

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    10. XM_016957762.4 → XP_016813251.1  receptor-type tyrosine-protein phosphatase U isoform X10

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00

    11. XM_024357454.3 → XP_024213222.1  receptor-type tyrosine-protein phosphatase U isoform X13

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00
      Conserved Domains (4) summary
      cd00047
      Location:930 → 1163
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:121 → 216
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:229 → 312
      fn3; Fibronectin type III domain
      pfam00102
      Location:643 → 868
      Y_phosphatase; Protein-tyrosine phosphatase

    12. XM_054664991.2 → XP_054520966.1  receptor-type tyrosine-protein phosphatase U isoform X12

    13. XM_016957772.4 → XP_016813261.1  receptor-type tyrosine-protein phosphatase U isoform X11

      UniProtKB/TrEMBL
      A0A2I3SEZ5, A0A2J8JCK4, A0A6D2YC00
    Nucleotide Protein
    Heading Accession and Version

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