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    PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 454422, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PAFAH1B1provided by VGNC
    Official Full Name
    platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:9502
    Locus tag
    CK820_G0046788
    See related
    Ensembl:ENSPTRG00000008551
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    LIS-1; PAFAHA
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (13088036..13176661)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (735088..827064, complement)

    Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene eukaryotic translation initiation factor 4A1pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134808845 Neighboring gene clustered mitochondria homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dynein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule plus-end binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in microtubule organizing center organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nuclear migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retrograde axonal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha
    Names
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAFAH alpha
    lissencephaly-1 protein
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
    NP_001029263.1
    XP_016785987.1
    XP_054525740.1
    XP_063654068.1
    XP_063654069.1
    XP_063654070.1
    XP_063654071.1
    XP_063654072.1
    XP_063654073.1
    XP_063654074.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034091.1 → NP_001029263.1  platelet-activating factor acetylhydrolase IB subunit alpha

      See identical proteins and their annotated locations for NP_001029263.1

      Status: PROVISIONAL

      Source sequence(s)
      AY665285
      UniProtKB/Swiss-Prot
      Q5IS43
      UniProtKB/TrEMBL
      A0A2I3SN67
      Related
      ENSPTRP00000078363.1, ENSPTRT00000102460.1
      Conserved Domains (5) summary
      COG2319
      Location:97 → 410
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08513
      Location:9 → 35
      LisH; LisH
      pfam10211
      Location:6 → 80
      Ax_dynein_light; Axonemal dynein light chain
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      13088036..13176661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063798001.1 → XP_063654071.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    2. XM_016930498.4 → XP_016785987.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2I3SN67, A0A2J8JL03, A0A6D2X599, H2QBV7
      Related
      ENSPTRP00000014595.3
      Conserved Domains (3) summary
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:10 → 34
      LisH

    3. XM_063798004.1 → XP_063654074.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

    4. XM_063798003.1 → XP_063654073.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

    5. XM_063797999.1 → XP_063654069.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    6. XM_063797998.1 → XP_063654068.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    7. XM_054669765.2 → XP_054525740.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    8. XM_063798000.1 → XP_063654070.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    9. XM_063798002.1 → XP_063654072.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2J8JL03, A0A6D2X599, H2QBV7

    RNA

    1. XR_010152717.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IS43.3 GenPept UniProtKB/Swiss-Prot:Q5IS43

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