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    COMT catechol-O-methyltransferase [ Canis lupus familiaris (dog) ]

    Gene ID: 445450, updated on 5-Mar-2024

    Summary

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    Official Symbol
    COMTprovided by VGNC
    Official Full Name
    catechol-O-methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:39501
    See related
    Ensembl:ENSCAFG00845028665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (30763075..30783341, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (29318554..29324118, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (29522581..29528148, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (28811616..28817179, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (28436974..28442538, complement)

    Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA mir-185 Neighboring gene ARVCF delta catenin family member Neighboring gene thioredoxin reductase 2 Neighboring gene G protein subunit beta 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours. Canadas A, et al. Vet Comp Oncol, 2018 Dec. PMID 30168237
    2. Association between COMT SNP variation and timidity in Golden and Labrador Retrievers. Luo D, et al. Anim Genet, 2018 Aug. PMID 29932467
    3. Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors. Dias Pereira P, et al. Vet Pathol, 2009 Nov. PMID 19605895
    4. Breed differences in genotype and allele frequency of catechol O-methyltransferase gene polymorphic regions in dogs. Masuda K, et al. J Vet Med Sci, 2004 Feb. PMID 15031547
    5. Catechol-O-methyltransferase and the clinical features of psychosis. McClay JL, et al. Am J Med Genet B Neuropsychiatr Genet, 2006 Dec 5. PMID 16921496

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNPs associated with progression and biological behavior of mammary tumors
      Title: Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours.
    2. genotypes and haplotypes of the COMT gene were significantly and highly correlated with the timidity of Golden and Labrador Retrievers
      Title: Association between COMT SNP variation and timidity in Golden and Labrador Retrievers.
    3. Dogs carrying both known polymorphisms of COMT were more likely to develop recurrence of mammary lesions.
      Title: Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors.
    4. A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus confers a modest affective vulnerability to psychosis.
      Title: Catechol-O-methyltransferase and the clinical features of psychosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables catechol O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catecholamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catechol O-methyltransferase
    Names
    O-methyltransferase
    NP_001004074.1
    XP_038292001.1
    XP_038292002.1
    XP_038292003.1
    XP_038292004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004074.1 → NP_001004074.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_001004074.1

      Status: PROVISIONAL

      Source sequence(s)
      AY340812
      UniProtKB/TrEMBL
      A0A8P0SIL1, Q60F99, Q69FG4, Q69FG6
      Related
      ENSCAFP00845039737.1, ENSCAFT00845050690.1
      Conserved Domains (1) summary
      pfam13578
      Location:63 → 171
      Methyltransf_24; Methyltransferase domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051830.1 Reference ROS_Cfam_1.0

      Range
      30763075..30783341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038436073.1 → XP_038292001.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0NTN1, A0A8I3Q5W5
      Related
      ENSCAFP00845039727.1, ENSCAFT00845050677.1
      Conserved Domains (1) summary
      COG4122
      Location:49 → 241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    2. XM_038436074.1 → XP_038292002.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0NTN1, A0A8I3Q5W5
      Conserved Domains (1) summary
      COG4122
      Location:49 → 241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    3. XM_038436075.1 → XP_038292003.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0NTN1, A0A8I3Q5W5
      Conserved Domains (1) summary
      COG4122
      Location:49 → 241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    4. XM_038436076.1 → XP_038292004.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8C0NTN1, A0A8I3Q5W5
      Conserved Domains (1) summary
      COG4122
      Location:49 → 241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049286.1 Alternate UMICH_Zoey_3.1

      Range
      28811616..28817179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

      Range
      28436974..28442538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

      Range
      29522581..29528148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      29318554..29324118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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