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    Sec13 Secretory 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44437, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Sec13provided by FlyBase
    Official Full Name
    Secretory 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0024509
    Locus tag
    Dmel_CG6773
    See related
    AllianceGenome:FB:FBgn0024509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD03471; BEST:CK00043; CG6773; CK00043; Dmel\CG6773; Dsec13; GATOR2; l(3)01031; sec13; SEC13
    Summary
    Enables chromatin binding activity. Involved in several processes, including chitin-based larval cuticle pattern formation; ecdysone-mediated polytene chromosome puffing; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in chromatin; nucleoplasm; and polytene chromosome puff. Part of Seh1-associated complex. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; extended germ band embryo; and gut section. Orthologous to human SEC13 (SEC13 homolog, nuclear pore and COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Sec13 in Genome Data Viewer
    Location:
    94E13-94E13; 3-78 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23356278..23358531)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19182000..19184253)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon subunit 1 Neighboring gene ATP synthase, coupling factor 6 Neighboring gene Ribosomal protein S3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rop, the Sec1/Munc18 homolog in Drosophila, is required for furrow ingression and stable cell shape during cytokinesis. DeBruhl H, et al. J Cell Sci, 2016 Jan 15. PMID 26631487, Free PMC Article
    2. Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions. Raices M, et al. Nat Rev Mol Cell Biol, 2012 Nov. PMID 23090414
    3. From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression. Burns LT, et al. Mol Cell Biol, 2014 Jun. PMID 24615017, Free PMC Article
    4. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
    5. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Capelson M, et al. Cell, 2010 Feb 5. PMID 20144761, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle budding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysone-mediated polytene chromosome puffing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein exit from endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of GATOR2 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 13
    Names
    CG6773-PA
    CG6773-PB
    Sec13 ortholog
    Sec13-PA
    Sec13-PB
    sec13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23356278..23358531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300551.1 → NP_001287480.1  secretory 13, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KLW8, Q9V3J4
      Conserved Domains (2) summary
      sd00039
      Location:60 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_143720.4 → NP_651977.1  secretory 13, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KLW8, Q9V3J4
      Related
      FBpp0083801
      Conserved Domains (2) summary
      sd00039
      Location:60 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3J4.1 Q9V3J4

    Gene LinkOut

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