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    Acf ATP-dependent chromatin assembly factor large subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43751, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Acfprovided by FlyBase
    Official Full Name
    ATP-dependent chromatin assembly factor large subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027620
    Locus tag
    Dmel_CG1966
    See related
    AllianceGenome:FB:FBgn0027620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    175K protein; ACF; Acf-1; ACF/CHRAC; acf1; Acf1; ACF1; CAF; CG1966; CHRAC; CHRAC-175; dACF; dAcf1; dCHRAC; Dmel\CG1966; p170; p170/p185; p175
    Summary
    Enables ATPase activator activity and DNA binding activity. Involved in several processes, including nucleosome organization; regulation of ATPase activity; and regulation of gene expression. Located in nucleus. Part of ACF complex and CHRAC. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; endoderm anlage; extended germ band embryo; and female-specific anatomical entity. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31793981..31799799)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27619703..27625521)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene septin interacting protein 3 Neighboring gene uncharacterized protein Neighboring gene fat facets Neighboring gene Methylcrotonoyl-CoA carboxylase 1 Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 100a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of nucleosome remodelers CHRAC/ACF does not sensitize early Drosophila embryos to X-rays. Scacchetti A, et al. MicroPubl Biol, 2020 Jul 30. PMID 32760884, Free PMC Article
    2. CHRAC/ACF contribute to the repressive ground state of chromatin. Scacchetti A, et al. Life Sci Alliance, 2018 Jan. PMID 30456345, Free PMC Article
    3. ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4. Klinker H, et al. PLoS One, 2014. PMID 24516652, Free PMC Article
    4. A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling. Strohner R, et al. Nat Struct Mol Biol, 2005 Aug. PMID 16025127
    5. The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression. Livengood JA, et al. Nucleic Acids Res, 2004. PMID 15155851, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACF1 has a role in nucleosome remodeling during Drosophila oogenesis
      Title: A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis.
    2. Altering the levels of ACF1 leads to global and variegated deviations from normal chromatin organisation with pleiotropic defects.
      Title: Developmental role for ACF1-containing nucleosome remodellers in chromatin organisation.
    3. The chromatin remodeler Acf1 directly represses Wg transcriptional targets.
      Title: The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets.
    4. ACF1 facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9).
      Title: HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ACF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ACF complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent chromatin assembly factor large subunit
    Names
    ATP-utilizing chromatin assembly and remodeling factor
    Acf-PA
    CG1966-PA
    chromatin accessibility complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31793981..31799799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080486.3 → NP_536734.2  ATP-dependent chromatin assembly factor large subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536734.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9T4, Q9Y0W1
      Related
      FBpp0085204
      Conserved Domains (8) summary
      cd05504
      Location:1349 → 1463
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      smart00249
      Location:1244 → 1284
      PHD; PHD zinc finger
      smart00571
      Location:346 → 411
      DDT; domain in different transcription and chromosome remodeling factors
      cd15543
      Location:1064 → 1109
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam10537
      Location:26 → 125
      WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
      pfam15612
      Location:505 → 554
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:637 → 666
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      pfam15614
      Location:775 → 813
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BI37 Q5BI37
    Q95RV8 Q95RV8
    Q9NG24 Q9NG24
    Q9V9T4 Q9V9T4
    Q9Y0W1 Q9Y0W1

    Gene LinkOut

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