ccdc103 coiled-coil domain containing 103 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccdc103provided by ZNC
Official Full Name: coiled-coil domain containing 103provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-253
See related: Ensembl:ENSDARG00000053455 AllianceGenome:ZFIN:ZDB-GENE-040718-253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: smh; zgc:100838
Summary: Acts upstream of or within axonemal dynein complex assembly; cerebrospinal fluid circulation; and embryonic heart tube morphogenesis. Located in axoneme. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; otic placode; peripheral olfactory organ; and spinal cord neural tube. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human CCDC103 (coiled-coil domain containing 103). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (33420219..33422734, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (33288505..33291020, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia.
Title: Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonemal dynein complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cilium movement involved in extracellular fluid movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coiled-coil domain-containing protein 103

Names: protein schmalhans

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002753.3 → NP_001002753.1 coiled-coil domain-containing protein 103

See identical proteins and their annotated locations for NP_001002753.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein

Source sequence(s)

CR396582

UniProtKB/Swiss-Prot

Q6DGB6

Related

ENSDARP00000069975.3, ENSDART00000075493.4

Conserved Domains (2) summary

pfam13877
Location:98 → 188

RPAP3_C; Potential Monad-binding region of RPAP3

pfam15867
Location:7 → 74

Dynein_attach_N; Dynein attachment factor N-terminus

RNA

NR_131952.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional splice site at the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

CR396582