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    shams [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43008, updated on 11-Apr-2024

    Summary

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    Official Symbol
    shamsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039273
    Locus tag
    Dmel_CG9996
    See related
    AllianceGenome:FB:FBgn0039273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9996; dibeta3GnT5; Dmel\CG9996; Shams
    Summary
    Enables protein xylosyltransferase activity. Involved in negative regulation of Notch signaling pathway and protein O-linked glycosylation. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human GXYLT1 (glucoside xylosyltransferase 1) and GXYLT2 (glucoside xylosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96B20-96B20; 3-86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25072729..25074607, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20898451..20900329, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene forkhead domain 96Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meeting Between Rumi and Shams in Notch Signaling; Implications for Pain Management: A Narrative Review. Rajaei S, et al. Anesth Pain Med, 2019 Feb. PMID 30881911, Free PMC Article
    2. Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. Lee TV, et al. PLoS Genet, 2017 Apr. PMID 28394891, Free PMC Article
    3. Negative regulation of notch signaling by xylose. Lee TV, et al. PLoS Genet, 2013 Jun. PMID 23754965, Free PMC Article
    4. Significant Roles of Notch O-Glycosylation in Cancer. Wang W, et al. Molecules, 2022 Mar 9. PMID 35335147, Free PMC Article
    5. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    shams
    Names
    CG9996-PB
    shams-PB
    NP_001097911.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25072729..25074607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104441.2 → NP_001097911.1  shams [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBY3
      Conserved Domains (2) summary
      COG1442
      Location:64 → 270
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      cl11394
      Location:48 → 343
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBY3 Q9VBY3

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