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    WLS wntless Wnt ligand secretion mediator [ Gallus gallus (chicken) ]

    Gene ID: 424707, updated on 3-Apr-2024

    Summary

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    Symbol
    WLSprovided by CGNC
    Full Name
    wntless Wnt ligand secretion mediatorprovided by CGNC
    Primary source
    CGNC:8538
    See related
    Ensembl:ENSGALG00010023422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GPR177
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (28408242..28431888, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (28420249..28443919, complement)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene growth arrest and DNA damage inducible alpha Neighboring gene G protein subunit gamma 12 Neighboring gene microRNA 6653 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2-like Neighboring gene RPE65, retinoid isomerohydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Concentration-dependent effects of WNTLESS on WNT1/3A signaling. Galli LM, et al. Dev Dyn, 2014 Sep. PMID 24866848, Free PMC Article
    2. Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling. Galli LM, et al. Exp Cell Res, 2016 Sep 10. PMID 27492485, Free PMC Article
    3. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Bartscherer K, et al. Cell, 2006 May 5. PMID 16678096
    4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in organelle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein wntless homolog
    Names
    G protein-coupled receptor 177
    integral membrane protein GPR177
    wntless homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031294.2 → NP_001026465.2  protein wntless homolog precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000239
      UniProtKB/Swiss-Prot
      Q5ZLR1
      UniProtKB/TrEMBL
      F1P376
      Related
      ENSGALP00010034722.1, ENSGALT00010057086.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      28408242..28431888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046944542.1 → XP_046800498.1  protein wntless homolog isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      28420249..28443919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZLR1.1 GenPept UniProtKB/Swiss-Prot:Q5ZLR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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