U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Septin2 Septin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42438, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Septin2provided by FlyBase
    Official Full Name
    Septin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014029
    Locus tag
    Dmel_CG4173
    See related
    AllianceGenome:FB:FBgn0014029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38961; CG4173; Dmel\CG4173; DSep2; dSEPT2; sep2; Sep2
    Summary
    Enables GTPase activity and protein homodimerization activity. Involved in growth of a germarium-derived egg chamber; imaginal disc development; and regulation of cell cycle. Part of septin complex. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; germ layer; presumptive embryonic/larval system; and stage 5 embryo. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including SEPTIN11 (septin 11) and SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    92F2-92F2; 3-69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20586129..20588356, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16411851..16414078, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle 14 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46044 Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis. O'Neill RS, et al. Genome, 2013 Dec. PMID 24433211
    2. Purification of cytoskeletal proteins using peptide antibodies. Field CM, et al. Methods Enzymol, 1998. PMID 9751906
    3. Purification and assay of a septin complex from Drosophila embryos. Oegema K, et al. Methods Enzymol, 1998. PMID 9751888
    4. Septins may form a ubiquitous family of cytoskeletal filaments. Cooper JA, et al. J Cell Biol, 1996 Sep. PMID 8830765, Free PMC Article
    5. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. Field CM, et al. J Cell Biol, 1996 May. PMID 8636235, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
      Title: Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
    2. Phosphorylation of Pnut in the early stages of Drosophila embryo development affects association of the Sep1-Sep2 complex with the membrane and is important for viability.
      Title: Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability.
    3. It has been found that Sep2 is uniquely required for follicle cell encapsulation of female germline cysts, and that Sep2 and Sep5 are redundant for follicle cell proliferation.
      Title: Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.
    4. Results show that Sep2 Sep5 double mutants have an early pupal lethal phenotype and lack imaginal discs, suggesting that these genes have redundant functions during imaginal cell proliferation.
      Title: The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    septin 2
    Names
    CG4173-PA
    CG4173-PB
    Septin2-PA
    Septin2-PB
    septin
    septin-2
    septin2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20586129..20588356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079693.4 → NP_524417.1  septin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54359, Q24092, Q9VDK8
      Related
      FBpp0083352
      Conserved Domains (2) summary
      PTZ00121
      Location:285 → 393
      PTZ00121; MAEBL; Provisional
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family

    2. NM_001275835.1 → NP_001262764.1  septin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGJ1
      Conserved Domains (1) summary
      cd01850
      Location:1 → 249
      CDC_Septin; CDC/Septin GTPase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGJ1 A0A0B4KGJ1
    P54359.2 P54359

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous